Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1,2,3-triazole Derivatives

doi:10.11944/j.issn.1000-0518.2018.11.170421

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (11): 1325-1330.DOI: 10.11944/j.issn.1000-0518.2018.11.170421

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Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1,2,3-triazole Derivatives

LI Yuanxiang^a^b^c^*(),LIU Yilin^a^b,LEI Sufang^a,CHEN Dizhao^a^c,BO Rui^a,LI Sunyong^a

^aCollege of Chemistry and Materials Engineering
^bInstitute of Organic Synthesis
^cHunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material,Huaihua University,Huaihua,Hu'nan 418008,China

Received:2017-11-22 Accepted:2018-02-07 Published:2018-10-31 Online:2018-10-31
Contact: LI Yuanxiang
Supported by:
Supported by the Natural Science Foundation of Hu'nan Province(No.2016JJ4072), the Scientific Research Fund of the Hu'nan Provincial Education Department(No.16A165), the Open Fund Project of Hu'nan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material(No.HGY201605), the Construct Program of the Key Discipline in Huaihua University

Abstract

Abstract:

1,2,3-Triazole compounds show a wide range of biological activities. In order to find new compounds with bactericidal activity, a series of 2-substituted-4-aryl-2H-1,2,3-triazoles was synthesized from benzaldehyde or substituted benzaldehyde, nitromethane and sodium azide in 51% to 91% yields. The structures of these compounds were characterized by nuclear magnetic resonance spectroscopy(NMR), mass spectra and elemental analyses. Most of these compounds show the preliminary antibacterial activity against Gibberella zeae and Phytophythora capsici in vitro, in 25 mg/L concentration. Among them, compound 3a shows 80.4% activity of against Gibberella zeae, compound 3b shows 78.2% activity of against Botrytis cinerea, compounds 3a and 3h show 70.3%, 75.9% activities of against Sclerotonia sclerotiorum, respectively.

Key words: triazole, structure characterization, fungicidal activity

LI Yuanxiang,LIU Yilin,LEI Sufang,CHEN Dizhao,BO Rui,LI Sunyong. Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1,2,3-triazole Derivatives[J]. Chinese Journal of Applied Chemistry, 2018, 35(11): 1325-1330.

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Synthesis and Fungicidal Activity of 2-Substituted-4-aryl-2H-1,2,3-triazole Derivatives

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