High Efficient Synthesis of 1-Azabicyclo[2.2.2]octane

doi:10.3724/SP.J.1095.2012.20014

Chinese Journal of Applied Chemistry

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High Efficient Synthesis of 1-Azabicyclo[2.2.2]octane

ZHANG Huichen¹, CHEN Xiaojun², WANG Lixia¹, ZHAO Zhen¹, LIN Fangqin¹, GUAN Shiyou^1*

(1.School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;
2.Guangzhou Tinci Materials Technology Co.,Ltd.,Guangzhou 510760,China)

Received:2012-01-12 Revised:2012-03-17 Published:2012-12-10 Online:2012-12-10
Contact: Shiyou Guan

Abstract

Abstract: 1-Azabicyclo[2.2.2]octane(quinuclidine) was obtained via the direct intramolecular dehydration reaction of 4-(2-hydroxyethyl) piperidine vapor in presence of CNM-3, a solid acidic catalyst. The yield of quinuclidine can reach 76.8% at 425 ℃ for 4 h with the highest yield up to 84.3%. Due to the easy accessible of the precursors, the established method is believed to be promising for the scale-up of quinuclidine.

Key words: azabicyclo[2.2.2]octane, quinuclidine, high effect, (hydroxyethyl) piperidine, solid acidic catalyst

CLC Number:

O622.6

ZHANG Huichen1, CHEN Xiaojun2, WANG Lixia1, ZHAO Zhen1, LIN Fangqin1, GUAN Shiyou1*. High Efficient Synthesis of 1-Azabicyclo[2.2.2]octane[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.20014.

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High Efficient Synthesis of 1-Azabicyclo[2.2.2]octane

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