Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole

doi:10.3724/SP.J.1095.2012.00339

Chinese Journal of Applied Chemistry

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Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole

ZHENG Yuguo^1,2, GUO Qingqing^1,2, XIONG Zhuang¹, HE Yong¹, YANG Tao¹, LU Ping¹, WEI Xue¹, XUE Wei^1*

(1.Key Laboratory of Green Pesticide and Bioengineering,Ministry of Education,Research and
Development Center for Fine Chemicals,Guizhou University,Guiyang 550025,China;
2.Department of Chemistry and Biological,Xingyi Normal University of Nationalities,Xingyi 562400,China)

Received:2011-07-29 Revised:2011-10-03 Published:2012-07-10 Online:2012-07-10

Abstract

Abstract: Thirteen novel bisamides compounds containing methoxy and benzothiazole were synthesized. Their structures were characterized by 1H NMR, 13C NMR, IR and elemental analyses. Preliminary bioassay showed that some of them exhibited certain anti-CMV activities, and some compounds posed antitumor activity toward PC3 cells in vitro by MTT method. The antiproliferation activity of compound 4f to PC3 cells was 74.2% at the concentration of 10 μmol/L.

Key words: bisamides, benzothiazole, methoxy, bioactivity

CLC Number:

O626

ZHENG Yuguo1,2, GUO Qingqing1,2, XIONG Zhuang1, HE Yong1, YANG Tao1, LU Ping1, WEI Xue1, XUE Wei1*. Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.00339.

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Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole

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