Chinese Journal of Applied Chemistry ›› 1997, Vol. 0 ›› Issue (4): 88-90.

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Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex

Liu Xiang1, Li Jiguo2, Zhang Zheng2   

  1. 1. Department of Chemical Engineering, Wuxi University of Light Industry, Wuxi 214036;
    2. Department of Chemistry, Nanjing University, Nanjing
  • Received:1996-10-25 Revised:1997-04-22 Published:1997-08-10 Online:1997-08-10

Abstract: A chiral complex, in situ prepared from (-) quinine and CoCl2 was used as catalyst for asymmetric reduction of aromatic prochiral ketones: p-R2C6H4COR1 (R1, R2 shown in Tab.1) and some products with moderate enantiomeric excesses were obtained. Effects of KBH4 and LiAlH4 as reductant and reaction temperature and time on the reaction were investigated.

Key words: chiral complex, asymmetric reduction, aromatic prochiral ketone