Synthesis and Degradation Behavior of Poly(DL-Lactide)for Ophthalmic Application

Chinese Journal of Applied Chemistry ›› 1997, Vol. 0 ›› Issue (2): 102-104.

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Synthesis and Degradation Behavior of Poly(DL-Lactide)for Ophthalmic Application

Zhuo Renxi¹, Yin Chao¹, Wu Yinnan¹, Zhu Lei², Zhen Shuiqing²

1. Department of Chemistry, Wuhan University, Wuhan 430072;
2. Xiehe Hospital, Tongji Medical University, Wuhan

Received:1996-08-18 Revised:1997-01-17 Published:1997-04-10 Online:1997-04-10

Abstract

Abstract: The application of poly(DL-lactide)(PLA)as a biodegradable ophthalmic implant has been studied. The PLA was synthesized from DL-lactide by bulk ring opening polymerization initiated by stannous 2-ethylhexanoate. Both the pressure of polymerization system and the mole ratio of monomer to initiator showed a marked influence on the relative molecular weights of PLA. The in vitro and in vivo degradation of PLA has been investigated in 0.2 mol/L Na₂HPO₄ NaH₂PO₄ solution in rabbits eyes.

Key words: polylactide, synthesis, biodegradation, ophthalmic implant

Zhuo Renxi, Yin Chao, Wu Yinnan, Zhu Lei, Zhen Shuiqing. Synthesis and Degradation Behavior of Poly(DL-Lactide)for Ophthalmic Application[J]. Chinese Journal of Applied Chemistry, 1997, 0(2): 102-104.

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Synthesis and Degradation Behavior of Poly(DL-Lactide)for Ophthalmic Application

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