Chinese Journal of Applied Chemistry ›› 1992, Vol. 0 ›› Issue (4): 35-40.

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THE INHIBITION EFFECT OF SUBSTITUTED 2-CHLOROBENZOYL PHENYL UREA ON CHINTIN SYNTHESIS

Lu Zhonge1, Sun Daqing1, Li Kai1, Chen Keqian1, Zhang Yingkuo2, Zhao Xuezhong2   

  1. 1. Department of Chemistry, Suzhou University, Suzhou 215006;
    2. Institute of Military Medical Science, Nanjing
  • Received:1991-06-14 Revised:1991-06-14 Published:1992-08-10 Online:1992-08-10

Abstract: The quantitative structure-activity relationships (QSAR) have been studied between larvicidal activity against second instar larvae of Culex Pipiens Pallens and substituted 2-chlorobenzoyl phenyl urea or thiourea. From QSAR study, some important structure factors influencing the larvicidal activity of this series are found. Electronic parameter is the most important factor influencing the lavicidal activity, and some compounds hare the same insecticidal activity as 2,6-difluorobenzoyl-4-chlorophenyl urea(PH6040).

Key words: chintin synthesis inhibitor, chlorobenzoyl (4-substituted phenyl)urea, quantitative structure activity retationships (QSAR)