SYNTHESIS OF p-BROMOPHENACYL-2,3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY

Chinese Journal of Applied Chemistry ›› 1989, Vol. 0 ›› Issue (5): 44-46.

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SYNTHESIS OF p-BROMOPHENACYL-2,3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY

Yang Baokang, Jiang Caihua, Hu Bingfang

Institute of Applied Chemistry, Beijing Agricultural University, Institute of Plant Protection, Chinese Agricultural Acadamy, Beijing

Received:1988-12-30 Revised:1989-03-28 Published:1989-10-10 Online:1989-10-10

Abstract

Abstract: Some novel p-bromophenacyl-2,3-oxirane carboxylic esters were synthesized by Darzen′s condensation and esterification. The compounds were characterized by IR, ¹H NMR spec-troscopy and clemental analysis. The antifungal activity of the compounds in vitro has been determined. It is foundthat, in general, the antifungal activity against Pellicularia Sasakii was higher than thatagainst Macyodhane Kawatasukai and Gibberella Zeae. p-Bromophenacyl-3, 3-pentamethy1ene-2, 3-oxiranepropanoic ester(2), p-bromophenacyl-3-(β-naphthyl)-2,3-oxiranepropanoicester(11)were the most effective which can completely inhibite the mycelial growth of P. Sasakil, M. Kawatsukai in amount of 100 ppm. p-Bromophenacyl-5-methyl-2,3-oxiranehexanoic ester(1) and p-bromophenacyl-3-(p-chlorophenyl)-2, 3-oxiranebutanoic ester(7) were highlyactive against P. Sasakii.

Key words: p-Bormophenacy1-2, 3-oxirane carboxylic esters, Antifungal activity, Synthesis, Pesticide

Yang Baokang, Jiang Caihua, Hu Bingfang. SYNTHESIS OF p-BROMOPHENACYL-2,3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY[J]. Chinese Journal of Applied Chemistry, 1989, 0(5): 44-46.

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SYNTHESIS OF p-BROMOPHENACYL-2,3-OXIRANE CARSOXYLATE AND ITS ANTIFUNGAL ACTIVITY

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