Chinese Journal of Applied Chemistry ›› 1989, Vol. 0 ›› Issue (4): 22-25.

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OPTICALLY ACTIVE METHOXYTHRIN:SYNTHESIS AND THE STRUCTURE-ACTIVITY RELATION

Gu Kequan, Zou Xinzhou   

  1. Department of Chemistry, East China Nomal University, Shanghai
  • Received:1988-10-15 Revised:1989-01-23 Published:1989-08-10 Online:1989-08-10

Abstract: The Goffinet's method for resolution of (?)-trans-chrysanthemic acid and the Campbell's method for resolution of (?)-cis-chrysanthemic acid have been improved. The(+)-cis acid and the(-)-cis acid were resolved only by using quinine alone. Four esters were obtained by esterifacation.The results showed: (1)The biological activity of Methoxythrin is in relation of the configuration of chrysanthemic acid and the ester of(-)-(1R,3R)-trans acid showed the highest activity. (2)The biological activity of the compounds varies from insect to insect tested.

Key words: Methoxythrin, Optical activity, Structure-activity relation, Pesticide