Abstract:

The anti-tumor effects of the polymer-paclitaxel conjugate micelles and free paclitaxel on H22 liver cancer bearing mice were evaluated. After 10 days drug administration, the tumor volume inhibition rates(VIR) of free paclitaxel group, polymer-paclitaxel conjugate micelles group at doses of 3 mg/kg, and the micelles group at doses of 6 mg/kg are 22%, 49%, and 67%, respectively. In addition, the tumor weight inhibition rates (WIR) are 29%, 45%, and 47%, respectively. Protein expression results show that paclitaxel micelles group has higher expression of p53 and lower expression of bcl-2. All these results indicate that the anti-tumor effect of polymer-paclitaxel conjugate micelles is stronger than free paclitaxel.

Key words: H22 liver cancer mice, Paclitaxel, nano-micelles, conjugate drug