Abstract:

5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H-)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material. Effects including catalysts on acylation reaction, solvents on iodocyclization and catalysts, ligand, base and reaction temperature on Suzuki cross-coupling reaction have been investigated. Under optimum conditions, the yield of the product was up to 68.5%. The chemical structures of the intermediates and target product were characterized by IR, NMR and MS spectra.

Key words: Methyldiphenylbenzothiazepin-4(5H)-one, acylation reaction, iodocyclization, Suzuki cross-coupling reaction