Chinese Journal of Applied Chemistry

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (04): 494-496.DOI: 10.3724/SP.J.1095.2010.90420

• Original Articles • Previous Articles    

Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one

TAO Li-Ming1*, LIU Wen-Qi1, TAN Ni2, ZHOU Yun1   

  1. (1.Department of Chemistry and Life Science,Xiangnan University,Chenzhou 423000;
    2.School of Chemistry and Chemical Engineering,University of South China,Hengyang)
  • Received:2009-06-24 Revised:2009-07-28 Published:2010-04-10 Online:2010-04-10

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Abstract:

5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H-)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material. Effects including catalysts on acylation reaction, solvents on iodocyclization and catalysts, ligand, base and reaction temperature on Suzuki cross-coupling reaction have been investigated. Under optimum conditions, the yield of the product was up to 68.5%. The chemical structures of the intermediates and target product were characterized by IR, NMR and MS spectra.

Key words: Methyldiphenylbenzothiazepin-4(5H)-one, acylation reaction, iodocyclization, Suzuki cross-coupling reaction

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