Abstract:

A new anthraquinone derivative, 6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1)，together with five known compounds, 7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2)，2,4-Dihydroxy-6-[(1'E, 3'E)-penta-1',3'-dienyl]-benzaldehyde(3)，(E)-4-hydroxycinnamic acid methyl ester(4)，4-(4-hydroxyphenyl)-butan-2-ol(5)，and 4-hydroxybenzoic acid (6), were isolated from the marine mangrove endophytic fungus Fusarium sp. ZZF60 from the South China Sea. Their structures were elucidated by spectral data of IR, MS and NMR. In the preliminary bioassay, compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC50 values of 16 μmol/L and 23 μmol/L, respectively.