Abstract:

The A ring synthon 5 was synthesized from 1, 3-cyclohexanedione through methylation and carbonyl protection. The C ring synthon 9 was synthesized from 1-methoxy-2-methylbenzene by bromination, the addition of ethylene epoxide and further bromination. Compound 5 reacted with Grignard reagent of 9 and then performed cyclozation to afford the target molecule 11. All intermediates and target product were confirmed by IR, 1H NMR and HRMS. In conclusion, a simple synthetic route has been developed and the target molecule was successfully synthesized.