Chinese Journal of Applied Chemistry

Chinese Journal of Applied Chemistry ›› 2009, Vol. 26 ›› Issue (10): 1180-1183.

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Total Synthesis of Resveratrol (E)-dehydrodimer tetramethyl ether

ZHANG Cheng-Lu1, SHEN Hong-Jiang1, ZOU Li-Wei1, XU Yong-Ting2, GUANG Dong2, LI Yuan-Dong2, WANG Yang2, WANG Li-Dong2   

  1. (1.Liaoning Key Laboratory of Biotechology and Drug Discovery,College of Chemistry and Chemical Engineering, 2.Analytical Center,Liaoning Normal University,Dalian 116029)
  • Received:2008-09-18 Revised:2008-12-11 Published:2009-10-10 Online:2009-10-10

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Abstract:

The total synthesis of the title compound 10 was accomplished starting from 3, 5-dimethoxybenzoic acid (1) and p-hydroxybenzaldehyde (6) in eight steps via a strategy of biomimetic oxidative coupling. The structure of 10 which was confirmed by 1H NMR, 13C NMR, IR, HRMS analysis was 7, 8 - trans-7', 8'-trans-dimericstilbenoids (resveratrol (E)-dehydrodimer tetramethyl ether). In conclusion, the target compounds were successfully synthesized through the method in this paper.

Key words: Oxidative coupling； Resveratrol； Dimeric stilbenoids

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