Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy

doi:10.11944/j.issn.1000-0518.2018.12.180102

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (12): 1442-1448.DOI: 10.11944/j.issn.1000-0518.2018.12.180102

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Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy

WANG Yupeng^a^b,ZHOU Dongfang^a,CHENG Yanxiang^a,HUANG Yubin^a^*()

^a State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
^b Graduate School of the Chinese Academy of Sciences,Beijing 100039,China

Received:2018-04-08 Accepted:2018-06-06 Published:2018-12-05 Online:2018-12-10
Contact: HUANG Yubin
Supported by:
Supported by the National Natural Science Foundation of China(No.51673188)

Abstract

Abstract:

In this paper, the loading of both hemoglobin and photosensitizer drug heptamethine cyanine fluorescent small molecule:11-chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethylene quinone three-carbon cyanine iodide salt(IR780) was achieved by the isoelectric point method. The effect of the combined treatment of hemoglobin oxygen therapy and photodynamic therapy was studied. The morphology and stability of the hemoglobin/IR780 complex drug carrier were studied by transmission electron microscopy and dynamic light scattering, proving that the drug carrier maintains good stability under physiological conditions. The reactive oxygen species(ROS) detection of the drug in the solution and cell confirmed that the oxygen supply of hemoglobin could promote the production of ROS effectively. Meanwhile, it was also confirmed that the hemoglobin/IR780 complex drug carrier was more efficient to kill tumor cells than the single component IR780 drug in cell cytotoxicity experiments.

Key words: hemoglobin, photodynamic therapy, oxygen therapy

WANG Yupeng, ZHOU Dongfang, CHENG Yanxiang, HUANG Yubin. Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy[J]. Chinese Journal of Applied Chemistry, 2018, 35(12): 1442-1448.

References

[1]	Song G,Cheng L,Chao Y,et al. Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy[J]. Adv Mater,2017,29(32):1700996.
[2]	Bhaumik J,Mittal A K,Banerjee A,et al. Applications of Phototheranostic Nanoagents in Photodynamic Therapy[J]. Nano Res,2014,8(5):1373-1394.
[3]	Zhou F,Wang H,Chang J.Progress in the Field of Constructing Near-Infrared Light-Responsive Drug Delivery Platforms[J]. J Nanosci Nanotechnol,2016,16(3):2111-2125.
[4]	Gong H,Chao Y,Xiang J,et al. Hyaluronidase to Enhance Nanoparticle-Based Photodynamic Tumor Therapy[J]. Nano Lett,2016,16(4):2512-2521.
[5]	Conte C,Maiolino S,Pellosi D S,et al. Polymeric Nanoparticles for Cancer Photodynamic Therapy[J]. Topic Curr Chem,2016,370:61-112.
[6]	Cheng Y,Cheng H,Jiang C,et al. Perfluorocarbon Nanoparticles Enhance Reactive Oxygen Levels and Tumour Growth Inhibition in Photodynamic Therapy[J]. Nat Commun,2015,6:8785.
[7]	Prasad P,Gordijo C,Abbasi A,et al. Multifunctional Albumin MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response[J]. ACS Nano,2014,8(6):3202-3212.
[8]	Gao M,Hu A,Sun X,et al. Photosensitizer Decorated Red Blood Cells as an Ultrasensitive Light-Responsive Drug Delivery System[J]. ACS Appl Mater Interfaces,2017,9(7):5855-5863.
[9]	Alayash A I.Oxygen Therapeutics:Can We Tame Haemoglobin?[J]. Nat Rev Drug Discov,2004,3(2):152-159.
[10]	Liu X B,Cheng Q,Geng W,et al. Enhancement of Cisplatin-based TACE by a Hemoglobin-based Oxygen Carrier in an Orthotopic Rat HCC Model[J]. Artif Cell Nanomed B,2014,42(4):229-236.
[11]	Luo Z,Zheng M,Zhao P,et al. Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy[J]. Sci Rep,2016,6:23393.
[12]	Karaca A C,Low N,Nickerson M.Emulsifying Properties of Chickpea, Faba Bean, Lentil and Pea Proteins Produced by Isoelectric Precipitation and Salt Extraction[J]. Food Res Int,2011,44(9):2742-2750.

Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy

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