Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills

doi:10.11944/j.issn.1000-0518.2017.01.160132

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (1): 118-122.DOI: 10.11944/j.issn.1000-0518.2017.01.160132

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Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills

JIAN Yong^a^b^c,DING Ru^c,LIU Shu^b^*(),LIU Zhongying^b,SONG Fengrui^a,LIU Zhiqiang^a

^aNational Center of Mass Spectrometry in Changchun & Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
^bCollege of Pharmacy,Jilin University,Changchun 130021,China
^cThe Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550002,China

Received:2016-03-30 Accepted:2016-08-08 Published:2017-01-03 Online:2017-01-03
Contact: LIU Shu
Supported by:
Supported by the National Natural Science Foundation of China(No.81573574), the Science and Technology Development Foundation of Jilin Province(No.20130727002YY, No.20150101078JC)

Abstract

Abstract:

Acanthopanax leaf flavonoids liposome, acanthopanax leaf drop pills, and acanthopanax leaf flavonoid extract were fed to rats by intragastric administration to study the bioavailability and pharmacokinetics of hyperoside, and appropriate dosage form of acanthopanax leaf flavonoid by liquid chromatography-tandem mass spectrometry(LC-MS/MS). Pharmacokinetic data were processed with PKsolver software. The main pharmacokinetic parameters maximum plasma concentrations(C_max) are (210.24±10.3), (254.12±9.2), and (349.34±12.5) μg/L for acanthopanax leaf flavonoids liposome, acanthopanax leaf drop pills and acanthopanax leaf flavonoid extract, respectively; area under the curve from zero to t(AUC_0-t) is (30.7±2.7), (35.01±1.98), and (45.2±2.8) μg/(mL·min), respectively; mean retention time(MRT) is (334.42±75.36), (394.56±90.26), and (640.35±84.26) min, respectively. The results show that compared with acanthopanax leaf flavonoids extracts and acanthopanax leaf drop pills, the C_max and bioavailability of acanthopanax leaf flavonoids liposome are increased, the elimination rate of acanthopanax leaf flavonoids liposome is reduced. Liposome is expected to be the suitable dosage form of acanthopanax leaf flavonoids, and may become the new research direction in the field of chinese medicine chemistry.

Key words: acanthopanax, liposomes, dropping pills, bioavailability, pharmacokinetic

JIAN Yong, DING Ru, LIU Shu, LIU Zhongying, SONG Fengrui, LIU Zhiqiang. Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills[J]. Chinese Journal of Applied Chemistry, 2017, 34(1): 118-122.

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Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills

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