Ruthenium/Acid Co-catalyzed Synthesis of Quinoline Derivatives from o-Aminoarylmethanols and Terminal Arylalkynes

doi:10.11944/j.issn.1000-0518.2015.03.140250

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (3): 267-272.DOI: 10.11944/j.issn.1000-0518.2015.03.140250

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Ruthenium/Acid Co-catalyzed Synthesis of Quinoline Derivatives from o-Aminoarylmethanols and Terminal Arylalkynes

LIU Jianben^*, CHEN Shang

College of Chemistry and Chemical Engineering,Jishou University,Jishou,Hu'nan 416000,China

Received:2014-07-18 Accepted:2014-11-05 Published:2015-03-02 Online:2015-03-02
Contact: Jianben LIU
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Abstract

Abstract:

By using o-aminophenyl methanol as the starting material and undergoing a dehydrogenation reaction, [RuCl₂(p-cymene)]₂/AgOTf was finally employed as the co-catalyst system upon a systematical screening of catalysts, which enables the dehydrogenation of o-aminophenyl methanol to undergo a cross-coupling reaction with terminal aryl alkynes, affording a series of 2-aryl quinolines in 39% to 47% yields. The study has demonstrated a new method for the synthesis of quinolines from o-aminophenyl methanol and terminal aryl alkynes, which is an important complement to the synthesis of quinoline derivatives.

Key words: ruthenium catalysis, o-aminoaryl methanol, dehydrogenation, quinoline derivatives

CLC Number:

LIU Jianben, CHEN Shang. Ruthenium/Acid Co-catalyzed Synthesis of Quinoline Derivatives from o-Aminoarylmethanols and Terminal Arylalkynes[J]. Chinese Journal of Applied Chemistry, 2015, 32(3): 267-272.

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Ruthenium/Acid Co-catalyzed Synthesis of Quinoline Derivatives from o-Aminoarylmethanols and Terminal Arylalkynes

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