Bromination of 2-Methyl-1,8-naphthyridine Derivatives

doi:10.3724/SP.J.1095.2014.30642

Chinese Journal of Applied Chemistry

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Bromination of 2-Methyl-1,8-naphthyridine Derivatives

GOU Gaozhang^1,2, WU Na^1,2, SHI Ling^1,2, XU Shijuan^1,2, YAN Heping^1,2, LIU Wei^1,2*

(1.College of Science;2.Key Laboratory of Natural Pharmaceutical & Chemical Biology of
Yunnan Province,Honghe University,Mengzi 661100,China)

Received:2013-12-18 Revised:2014-04-29 Published:2014-10-09 Online:2014-10-09
Contact: Wei Liu

Abstract

Abstract: This paper reported the bromination of 2-methyl-1,8-naphthyridine derivatives. Monobrominated products, 2-bromomethyl-1,8-naphthyridine derivatives, and dibrominated byproducts were obtained with N-bromosuccimide(NBS) as the bromination agent under infrared light. Two synthetic conditions were evaluated. The yield of monobrominated products is up to 54.6% under the optimized condition of 2-methyl-1,8-naphthyrdine derivatives and NBS in molar ratio of 1∶1.2 under 500 W infrared light.

Key words: naphthyridine, N-bromosuccinimide, initiator

CLC Number:

O626.3

GOU Gaozhang1,2, WU Na1,2, SHI Ling1,2, XU Shijuan1,2, YAN Heping1,2, LIU Wei1,2*. Bromination of 2-Methyl-1,8-naphthyridine Derivatives[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30642.

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Bromination of 2-Methyl-1,8-naphthyridine Derivatives

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