Abstract:

This paper discussed the Ullmann reaction of aryl halides with nitrogen heterocycles catalyzed by copper(Ⅰ) iodide/ethylenediamine. The results showed that reaction was preferred for nitrogen heterocycles with lower pKa values. In addition, the reactions were also favorable for the electron-rich aryl halides with p-π conjugations, however, they became difficult for other electron-rich aryl halides.

Key words: Ullmann reaction, N-arylation reaction, nitrogen heterocycles, copper(Ⅰ) iodide/ethylenediamine catalyst