Synthesis of Chromium (Ⅲ) Complex of 2,6-Di(2’-imidazoline-2’-yl) Pyridine and Its Interaction with DNA

doi:10.3724/SP.J.1095.2010.90729

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (09): 1032-1037.DOI: 10.3724/SP.J.1095.2010.90729

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Synthesis of Chromium (Ⅲ) Complex of 2,6-Di(2’-imidazoline-2’-yl) Pyridine and Its Interaction with DNA

ZHANG Jin-Yan¹, XIAO Xiao-Ming¹*, JIANG Yan¹, TAN Nian-Yuan²

(1.College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081;
2.College of Chemistry and Chemical Engineering,Hunan Institute of Engineering,Xiangtan)

Received:2009-11-06 Revised:2010-01-22 Published:2010-09-10 Online:2010-09-10

Abstract

Abstract:

2,6-Di(2′-imidazoline-2′-yl)pyridine(L) was synthesized from pyridine 2,6-dicarboxylic acid and ethylenediamine under microwave irradiation without catalyst. Its chromium complex [CrL₂][NO₃]₃ was synthesized by the conventional method. The complex was characterized by IR spectrometry, elemental analysis, ¹H NMR, TG-DSC and molar conductivity. The bindings of these two compounds to DNA were investigated by UV spectrometry and viscosity measurement. It is believed that the ligand may bind to DNA by hydrogen bonding and grooveface binding and the complex bind to DNA by hydrogen bonding and external electrostatic binding. The calculation results from density functional theory(DFT) with hybrid functional B3LYP is good agreement with the experimental phenomena.

Key words: di(imidazolineyl)Pyridine, Chromium(Ⅲ) complex, Deoxyribonucleic Acid, Microwave Irradiation, DFT

CLC Number:

O626.1

ZHANG Jin-Yan1, XIAO Xiao-Ming1*, JIANG Yan1, TAN Nian-Yuan2. Synthesis of Chromium (Ⅲ) Complex of 2,6-Di(2’-imidazoline-2’-yl) Pyridine and Its Interaction with DNA[J]. Chinese Journal of Applied Chemistry, 2010, 27(09): 1032-1037.

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Synthesis of Chromium (Ⅲ) Complex of 2,6-Di(2’-imidazoline-2’-yl) Pyridine and Its Interaction with DNA

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