Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (05): 523-527.DOI: 10.3724/SP.J.1095.2010.90345
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HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hua*
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Abstract:
To develop a novel inhibitor of Mycobacterium tuberculosis, a new compound 5-[β-(2-hydroxylphenyl)propynoylamic]-5-deoxyadenosine was synthesized from the starting material of 2-iodine phenol via a series of reactions such as Sonogashira and condensation reactions. The experimental conditions were optimized. The structure of the compound was determined by 1H NMR, 13C NMR, IR and LC/MS.
Key words: MbtA, MbtB, inhibitor, nucleoside compounds, synthesis
CLC Number:
O625.6
HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hua*. Synthesis of the 5'-(2-hydroxylphenyl)-propynoylamide-5'-deoxy-aminoadenosine[J]. Chinese Journal of Applied Chemistry, 2010, 27(05): 523-527.
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URL: http://yyhx.ciac.jl.cn/EN/10.3724/SP.J.1095.2010.90345
http://yyhx.ciac.jl.cn/EN/Y2010/V27/I05/523