Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (05): 523-527.DOI: 10.3724/SP.J.1095.2010.90345

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Synthesis of the 5'-(2-hydroxylphenyl)-propynoylamide-5'-deoxy-aminoadenosine

HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hua*   

  1. (School of Pharmacy,Medical College of Soochow University,Suzhou 215123)
  • Received:2009-05-13 Revised:2009-08-29 Published:2010-05-10 Online:2010-05-10

Abstract:

To develop a novel inhibitor of Mycobacterium tuberculosis, a new compound 5-[β-(2-hydroxylphenyl)propynoylamic]-5-deoxyadenosine was synthesized from the starting material of 2-iodine phenol via a series of reactions such as Sonogashira and condensation reactions. The experimental conditions were optimized. The structure of the compound was determined by 1H NMR, 13C NMR, IR and LC/MS.

Key words: MbtA, MbtB, inhibitor, nucleoside compounds, synthesis

CLC Number: