Preparation and Performance of Chitosan-Polyvinyl Alcohol-sodium Tripolyphosphate Complex Microparticles

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (01): 21-26.

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Preparation and Performance of Chitosan-Polyvinyl Alcohol-sodium Tripolyphosphate Complex Microparticles

HUANG Qiong-Yu, ZHANG Ming-Xia, LIU Fang, XIAO Xiu-Feng, LIU Rong-Fang*

(College of Chemistry and Materials Science，Key Laboratory of Polymer Science,
Fujian Normal University，Fuzhou 350007)

Received:2008-12-23 Revised:2009-04-09 Published:2010-01-10 Online:2010-01-10

Abstract

Abstract:

Chitosan/polyvinyl alcohol/sodium tripolyphosphate complex microparticles were prepared from chitosan, polyvinyl alcohol and sodium tripolyphosphate. The effects of CS content on complex microparticles and different ions, pH on the degree of equilibrium swelling were investigated. The component, structure and morphology of complex microparticles were characterized by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM). The results indicate that the chitosan-polyvinyl alcohol is a compatible system; the crystallization of PVA declines with the increase of CS content; the particle size is about 400-950 μm with rough surfaces. The equilibrium swelling tests show that with the increasing of CS content, the equilibrium swelling ratio increases firstly, then decreases; the equilibrium swelling ratio of CS/PVA/TPP complex microparticles in pH=3-8 solution is the best and in the same solution, that of microparticles decreases with the ion content increases.The microparticles have swelling-shrinking reversibility, implying that CS/PVA/TPP complex microparticles are pH/ion-sensitive and could provide experimental and theoretical basis for drug delivery system.

Key words: chitosan,polyvinyl alcohol,compatibility,degree of equilibrium swelling,drug carriers

CLC Number:

O636.1

HUANG Qiong-Yu, ZHANG Ming-Xia, LIU Fang, XIAO Xiu-Feng, LIU Rong-Fang*. Preparation and Performance of Chitosan-Polyvinyl Alcohol-sodium Tripolyphosphate Complex Microparticles[J]. Chinese Journal of Applied Chemistry, 2010, 27(01): 21-26.

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Preparation and Performance of Chitosan-Polyvinyl Alcohol-sodium Tripolyphosphate Complex Microparticles

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