Abstract:

Nitrendipine is among the second generation 1,4-dihydropyridine calcium antagonist, which was synthesized through the cyclo-condensation process of ethyl 2-(3-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate in a ionic liquid, n-butyl pyridinium tetrafluoroborate in yield of 96% . The ionic liquid can be recycled at least 5 times without loss in activity.