Abstract:

1,2-Cyclododecandione(4) was synthesized from dodecanedioic acid via esterification，acyloin condensation，oxidation in an overall yield of 43.1%. Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86.5%. compound (3) was obtained from (2) through acyloin condensation and the yield reached up to 63.1%, which was oxidized to 1,2-Cyclododecandione(4) using bromine water, a yield of 79%. The target compound was light yellow crystal and was characterized by means of IR、1H NMR and 13C NMR.

Key words: dodecanedioic acid； acyloin condensation； 1,2-Cyclododecandione