Chinese Journal of Applied Chemistry ›› 1991, Vol. 0 ›› Issue (4): 80-82.

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SPECTROSCOPIC STUDY ON THE INCLUSION OF DRUG MOLECULES WITH β-CYCLODEXTRIN

Guo Jun, Wang Wenyun   

  1. Changchun Institute of Applied Chenistry, Academia Sinica, Changchun 130022
  • Received:1990-07-21 Revised:1990-10-16 Published:1991-08-10 Online:1991-08-10

Abstract: The inclusion reactions of procaine, acetanilide and p-acetamidophenol with β-cyclodex-trin have been studied by means of absorption and fluorescence spectrometry and theirstability constants were calculated.Through inclusion, β-cyclodextrin enhances the fluores-cence emission of the drug molecules and, in particular, reduces the hydrolysis ofprocaine in aqueous solution.

Key words: β-cyclodextrin, procaine, acetanilide, p-acetanidophenol