Chinese Journal of Applied Chemistry ›› 1990, Vol. 0 ›› Issue (6): 61-63.

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SYNTHESIS AND RESOLUTION OF DL-NAPROXEN

Pan Yijun, Zhu Senming   

  1. Department of Chemistry, Hubei University, Wuhan 430063
  • Received:1990-01-03 Revised:1990-05-04 Published:1990-12-10 Online:1990-12-10

Abstract: dl-Naproxen(4)were obtained directly from 1-(6-methoxyl-2-naphthyl)propanone(2)via the catalytic aryl 1,2-rearrangement reaction in yield of 72.0%, which were resolutedby D-(-)-BGA(5)giving optical active s-(-)-Naproxen.

Key words: Naproxen, aryl 1,2-reariangement, resolution synthesis, optical isomer