Abstract: Using the widely accepted combination-chemotherapeutic antitumor drug amethopterin(abbreviated mtxH₂) as ligand, seven complexes with the composition of VO(mtx)·5H₂O,Mn(mtx)·5H₂O,(Femtx)₂O·10H₂O, Co(mtx)·5¹/₂H₂O, Ni(mtx)·6¹/₂H₂O, Cu(mtx)·4H²O, and Zn (mtx)·4H₂O, were prepared. The structures of the complexes were characterized and discussed by the thermogravi-metric, infrared, magnetic susceptibility, Mossbauer (for ferric complex) and electron para-magnetic resonance (for cupric and vanadyl complexes) measurements.

Key words: Amethopterin, Antitumor ligand, Transition metal complexes