Abstract: (S)-3-Chloro-1-phenyl-1-propanol was synthesized asymmetrically by using catalysts (R)-α,α-diphenyl-2-pyrrolidinemethanol, (1R,2S)-2-amino-1,2-diphenylethanol and (1R,2R)-1-amino-2-indanol with amine borane complexes, with a yield of 88.3%~93.8%, ee% 81.6~87.7. These amine borane complexes are more stable and safe than the borane-tetrahydrofuran complex and borane-methyl sulfide complex.

Key words: borane amine complex, CBS catalyst, (S)-chlorophenylpropanol, Fluoxetine