Abstract:

The solubility improvement of dexamethasone acetate by tetramethyl substituted cucurbit[6]urils(TMeQ[6]) was studied with the micro porous filter membrane separation technique, and the solid inclusion complex of TMeQ[6] and dexamethasone acetate was analyzed with the method of DTA.The results show that TMeQ[6] was able to increase the solubility of dexamethasone acetate, and the solubilization improvement could reach 4~17fold when the concentration of TMeQ[6] increased from 0.04 to 0.28 mmol/L. While the temperature increased from 10 ℃ to 70 ℃, the solubilization decreased in the range of 10~30 ℃, and then leveled off in the range of 40~70 ℃. At the same time, the solid inclusion complex of dexamethasone acetate with TMeQ[6] was prepared through cosolvent method, and its hostguest interaction was studied by DTA.

Key words: TMeQ[6], dexamethasoneacetate, solubilityimprovement, inclusioncomplex