Chinese Journal of Applied Chemistry ›› 2025, Vol. 42 ›› Issue (11): 1445-1460.DOI: 10.19894/j.issn.1000-0518.250123
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Peng-Yu CHANG, Cui-Ping CHEN, Kai XU, He-Bin WANG(
)
Received:2025-03-25
Accepted:2025-09-25
Published:2025-11-01
Online:2025-12-05
Contact:
He-Bin WANG
About author:wanghebin329@163.comSupported by:CLC Number:
Peng-Yu CHANG, Cui-Ping CHEN, Kai XU, He-Bin WANG. Research Progress on the Preparation of Metal-Polyphenol Networks and Their Applications in Drug Delivery and Diagnosis and Treatment[J]. Chinese Journal of Applied Chemistry, 2025, 42(11): 1445-1460.
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URL: http://yyhx.ciac.jl.cn/EN/10.19894/j.issn.1000-0518.250123
Fig.1 The basic structure of MPNs， common metal ions， and the schematic diagram of three common preparation methods： nanocoating［7］， direct self-assembly［8］ and layer-by-layer［9］
Fig.2 The mechanism of action of MPNs in anti-tumor， anti-oxidation， anti-bacterial and anti-inflammatory processes
Fig.3 MPN/CpG NPs defends against tumors by activating innate and adaptive immune responses［25］
Fig.4 （A） Schematic diagram of the preparation of PPFH based on the coordination between Fe3+ and polyphenols， and the dynamic disassembly process of these nanoparticles triggered by DFO； （B） Schematic diagram of the modulation of TECM by sequential injection of PPFH and DFO into the tail vein［31］
Fig.5 Schematic diagram of the anti-tumor process of Cu-Pic/HA nanoparticles by inducing enhanced pyroptosis and cuproptosis via global depletion of polyamines processes［35］
| Metal ions | Material composition | Mechanism/Anti | Ref. | |
|---|---|---|---|---|
Table 1 Structure types of MPNs that be used to antitumor
| Metal ions | Material composition | Mechanism/Anti | Ref. | |
|---|---|---|---|---|
Fig.6 Schematic diagram of the synthesis of PH/CuS/TM MNs and the promotion of wound healing. （A） Preparation of TM NPs and PH/CuS/TM MNs； （B） PH/CuS/TM MNs could eradicate bacteria， scavenging ROS and immunomodulation while promoting angiogenesis， enabling programmed treatment of diabetic wounds［34］
| Metal ions | Poly-phenol | Material composition | Mechanism/Anti-bacterial rate | Ref. |
|---|---|---|---|---|
| Fe3+ | TA | DHA@HA-TA-Fe | PTT/CDT/pH respond E.coil/S.aureus：＞99% | ［ |
| Cu2+ | EGCG | Borax@EGCG-Cu@PVA | Cu2+/CDT/PTT/pH respond E.coil：97.3% S.aureus：83.9% P.aeruginosa：69.1% C.albican：72.2% | ［ |
| Ga3+ | TA | TA-Ga | Ga3+/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Ce4+ | TA | HAP-HA@TA-Ce | PTT/CDT/pH respond S.aureus：＞99% | ［ |
| Fe3+ | EGCG | Au@EGCG-Fe | PTT/PDT/pH respond S.aureus：98.2% E.coil：＞99% | ［ |
| Fe3+ | TA | Ti3C2@TA-Fe@Ag | Ag+/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Fe3+ | TA | TA-Fe-SA | CDT/PTT/pH respond S.aureus：97.4% E.coil：93.9% | ［ |
| Fe3+ | TA | Ce6/TA-Fe | CDT/PDT/pH respond S.aureus：97.8% | ［ |
| Fe3+ | TA | TA-Fe-SA | CDT/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Fe3+ | PC | AuAg@PC-Fe | Ag+/PTT/pH respond P.Gingivalis：87.3% F.nucleatum：76.5% | ［ |
| Fe3+ | EGCG | BSA@EGCG-Fe | CDT/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
Table 2 Structure types of MPNs that be used to antibacterial
| Metal ions | Poly-phenol | Material composition | Mechanism/Anti-bacterial rate | Ref. |
|---|---|---|---|---|
| Fe3+ | TA | DHA@HA-TA-Fe | PTT/CDT/pH respond E.coil/S.aureus：＞99% | ［ |
| Cu2+ | EGCG | Borax@EGCG-Cu@PVA | Cu2+/CDT/PTT/pH respond E.coil：97.3% S.aureus：83.9% P.aeruginosa：69.1% C.albican：72.2% | ［ |
| Ga3+ | TA | TA-Ga | Ga3+/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Ce4+ | TA | HAP-HA@TA-Ce | PTT/CDT/pH respond S.aureus：＞99% | ［ |
| Fe3+ | EGCG | Au@EGCG-Fe | PTT/PDT/pH respond S.aureus：98.2% E.coil：＞99% | ［ |
| Fe3+ | TA | Ti3C2@TA-Fe@Ag | Ag+/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Fe3+ | TA | TA-Fe-SA | CDT/PTT/pH respond S.aureus：97.4% E.coil：93.9% | ［ |
| Fe3+ | TA | Ce6/TA-Fe | CDT/PDT/pH respond S.aureus：97.8% | ［ |
| Fe3+ | TA | TA-Fe-SA | CDT/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
| Fe3+ | PC | AuAg@PC-Fe | Ag+/PTT/pH respond P.Gingivalis：87.3% F.nucleatum：76.5% | ［ |
| Fe3+ | EGCG | BSA@EGCG-Fe | CDT/PTT/pH respond E.coil/S.aureus：＞99% | ［ |
Fig.7 Schematic illustration of （A） synthesis of GelMA/CMCSMAP-GACo hydrogel and （B） potential application mechanism in diabetic wound healing［61］
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