Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (4): 586-592.DOI: 10.19894/j.issn.1000-0518.230365

• Chemistry Teaching and Experiment Innovation • Previous Articles    

The Greening Improvement of Wittig Reaction Experiment

Yu-Fang LIU1, Cai-Hong ZHANG1, Mao-Sen YUAN2()   

  1. 1.School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China
    2.Northwest A&F University,Yangling 712100,China
  • Received:2023-11-20 Accepted:2024-02-27 Published:2024-04-01 Online:2024-04-28
  • Contact: Mao-Sen YUAN
  • About
  • Supported by:
    the Higher Education Teaching Reform and Innovation Project of Shanxi Provinc(J20220069)


In the traditional teaching of organic chemistry experimental courses, the teachers usually focus on the training of experimental skills and the investigation of factors such as the safety, canonicity and repeatability of the experiment, while paying insufficient attention to the green factors such as the economy of the reaction, the treatment of by-products and the amount of solvent usage. Besides, the assimilation of new knowledge for organic chemistry and new experimental skills is also seriously lagging behind. Therefore, the new methods and skills of organic synthesis in scientific research are introduced into the experimental teaching of organic chemistry, and the traditional Wittig reaction performing in a large number of organic solvents is modified into a solid phase grinding reaction without solvent, which makes the synthesis method greener, safer and more efficient. Three different styrene molecules with push-pull (D-π-A) structure are designed and synthesized, the reaction conditions are optimized, their spectral properties are compared, and their constitutive relationships are discussed, which not only introduces the concept of green chemistry, but also expands the knowledge, increases the novelty, exploratory and interestingness of the experiment, and enhances students' innovative ability.

Key words: Green chemistry, Wittig reaction, Solid-phase grinding synthesis, Structure-property analysis, Basic organic chemistry experiment

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