Advancement of Cyclodextrin-Based Host-Guest Drug Delivery System for Antitumor Therapy

doi:10.19894/j.issn.1000-0518.230055

Chinese Journal of Applied Chemistry ›› 2023, Vol. 40 ›› Issue (7): 964-975.DOI: 10.19894/j.issn.1000-0518.230055

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Advancement of Cyclodextrin-Based Host-Guest Drug Delivery System for Antitumor Therapy

Xiao-Ying LIU¹^,², Fang-Min CHEN², Hui-Juan ZHANG², Hai-Jun YU¹^,²()

^1.College of Pharmacy，Jiangxi University of Traditional Chinese Medicine，Nanchang 330004，China
^2.Center of Pharmaceutics，Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China
^3.Yangtze Delta Drug Advanced Research Institute，Nantong 226133，China

Received:2023-03-08 Accepted:2023-06-27 Published:2023-07-01 Online:2023-07-19
Contact: Hai-Jun YU
About author:hjyu@simm.ac.cn
Supported by:
National Natural Science Foundation of China(U22A20328)

Abstract

Abstract:

Malignant tumors are major diseases that threaten human health. The development of safe and efficient antitumor drugs and their delivery systems is an important guarantee for improving the efficacy of antitumor drugs. In recent years， cyclodextrin-based antitumor drug host-guest delivery systems have received much attention. Cyclodextrins are cyclic oligosaccharides obtained by amylolytic enzymes with an external hydrophilic internal hydrophobic structure， and have been widely used in gene therapy， immune cell therapy， immune-targeted therapy， and chemotherapy. This review summarizes the advances related to cyclodextrins as antitumor drug delivery carriers， and also provides a perspective and discussion on the opportunities and challenges of host-guest delivery systems in oncology therapy.

Key words: Malignant tumor, Host-guest drug delivery systems, Cyclodextrin inclusion compounds, Cyclodextrin conjugates, Cyclodextrin polymers

CLC Number:

O641.3

Xiao-Ying LIU, Fang-Min CHEN, Hui-Juan ZHANG, Hai-Jun YU. Advancement of Cyclodextrin-Based Host-Guest Drug Delivery System for Antitumor Therapy[J]. Chinese Journal of Applied Chemistry, 2023, 40(7): 964-975.

Figures/Tables 7

Fig.1 Structure of cyclodextrin

Table 1 Derivatives of CD and their properties

Type	Derivative	Characteristics	Example	Application	Ref.
Hydrophilic	Methylated	Good solubility in water as well as in organic solvents	RM-β-CD， per-O-methyl-β-CD	Nasal and ocular drug delivery systems	［34-38］
Hydrophilic	Hydroylated	Amorphous mixture and highly water soluble with very low toxicity	2-HP- β-CD， 3-HP- β-CD， 2，3-HP- β-CD	Parenteral， ocular and oral drug delivery systems	［39-41］
Hydrophilic	Alkylated	Poorly soluble in water， but soluble in organic solvents	2，6-Di-O-ethyl-β -CD， per-O-ethyl-β-CD	Parenteral and ocular drug delivery systems	［35， 42］
Ionizable	Anionic	Soluble at pH below 4 with low toxicity	SBE- β-CD	Parenteral drug delivery applications	［43-46］

Fig.2 Preparation of CD/drug inclusion complexes. A. Cyclodextrin inclusion complexes prepared by ultrasonic method， freeze-drying method in saturated aqueous solution； B. Cyclodextrin inclusion complexes prepared by co-volatilization method； C. Cyclodextrin inclusion complexes prepared by grinding method

Fig.3 Schematic diagram of CD polymer types

Fig.4 CD-based regorafenib complex for the treatment of colorectal cancer cancers. A. Preparation of RG@M-γ-CD； B. Schematic of RG@M-γ-CD inhibiting tumor cell proliferation［55］

Fig.5 Cyclodextrin-based nanoformulation enabling the co-administration of ginsenoside Rg3 and quercetin in colorectal cancer chemoimmunotherapy. A. Preparation of FA-targeted co-formulation； B. Schematic diagram of FA-targeted co-formulation-induced tumor immunogenic cell death treatment passages； C. Treatment plan and CRC progression within 35 days. Data are expressed as mean， standard deviation （n=5） *P＜0.05 and **P＜0.01； NS， no significant difference； D. Tumor IVIS images； E. In situ CRC mice treated with targeted co-formulation after removal of CD4+ or CD8+ T cells. Data are expressed as mean， standard deviation （n=4） *P＜0.05 and **P＜0.01； NS， no significant difference［71］

Fig.6 CD polymer-based drug delivery systems for cancer therapy. A. Synthesis of HCJSP； B. Cartoon schematic of HCJSP-induced stimulation of T cell activation and overcoming adaptive immune resistance to enhance photoimmunotherapy of pancreatic cancer； C. Synthetic route of cyclodextrin cross-linked polymer CDNP［77-79］

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Advancement of Cyclodextrin-Based Host-Guest Drug Delivery System for Antitumor Therapy

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