Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (12): 1392-1397.DOI: 10.11944/j.issn.1000-0518.2015.12.150178

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Catalytic Hantzsch Reaction in Aqueous Phase

JIN Jianzhonga*(),WEN Mingab,SHEN Chaoa,XU Tianhuac   

  1. aCollege of Biological and Environmental Engineering,Zhejiang Shuren University,Hangzhou,310015,China
    bCollege of Petroleum Chemical Industry,Changzhou University,Changzhou,Jiangsu 213164,China
    c Zhejiang Esigma Animal Health Co.,Ltd.,Haining,Zhejiang 314400,China
  • Received:2015-05-21 Accepted:2015-08-27 Published:2015-12-01 Online:2015-12-01
  • Contact: JIN Jianzhong
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21376058)

Abstract:

Aqueous catalytic Hantzsch reaction has been studied with aryl aldehyde, ethyl acetoacetate and ammonium salt. The influences of catalysts, substrate ratio and reaction temperature have been evaluated to optimize the reaction conditions. The optimum reaction conditions were:5 mmol benzaldehyde, 0.5 mmol DL-proline, 2.5 mmol (NH4)2CO3, 10 mL water, reaction time 5 h and reaction temperature 70 ℃. The productivity was 90.1% under the determined optimum reaction conditions. Recycle of catalysts did not show compromise of catalytic activity. The reaction displayed wide scope of aryl aldehyde. All products were confirmed with IR and NMR spectra. Reaction has the advantages of environment friendly, mild conditions, simple operation and high yield. Results show that aqueous catalytic Hantzsch reaction has wide applicability.

Key words: aqueous phase, Hantzsch reaction, catalytic cycle