应用化学 ›› 2009, Vol. 26 ›› Issue (6): 746-748.

• 研究简报 • 上一篇    

离子液体中钙拮抗剂尼群地平的合成

伍小云1,胡艾希2   

  1. 1. 南方医科大学
    2. 湖南大学化学化工学院
  • 收稿日期:2008-06-06 修回日期:2008-10-08 出版日期:2009-06-10 发布日期:2009-06-10
  • 通讯作者: 伍小云
  • 基金资助:
    广东省卫生厅医学科学技术研究基金

Synthesis of Calcium Antagonist Nitrendipine in Ionic Liquid

  • Received:2008-06-06 Revised:2008-10-08 Published:2009-06-10 Online:2009-06-10

摘要:

尼群地平属第二代1, 4-二氢吡啶类钙拮抗剂,2-(3-硝基亚苄基)乙酰乙酸乙酯和3-氨基-2-丁烯酸甲酯在离子液体1-丁基吡啶四氟硼酸盐中反应合成尼群地平,收率高达96%,离子液体回收套用至少5次,收率没有明显降低。

关键词: 1, 4-二氢吡啶类钙拮抗剂, 尼群地平, 离子液体

Abstract:

Nitrendipine is among the second generation 1,4-dihydropyridine calcium antagonist, which was synthesized through the cyclo-condensation process of ethyl 2-(3-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate in a ionic liquid, n-butyl pyridinium tetrafluoroborate in yield of 96% . The ionic liquid can be recycled at least 5 times without loss in activity.