化妆品级聚天冬氨酸钠的制备

doi:10.11944/j.issn.1000-0518.2020.08.200062

摘要/Abstract

摘要： 以L-天冬氨酸为起始原料通过缩合聚合合成了化妆品级的聚天冬氨酸钠(PASP)。详细考察了聚合温度、聚合时间及催化剂用量对聚合反应的影响,筛选出最优的聚合条件。利用核磁共振波谱仪(NMR)及凝胶渗透色谱(GPC)对PASP的结构及相对分子质量进行表征,同时也对其耐酸碱性、耐温性及兼容性进行了评估。结果表明,所制备的PASP颜色浅、气味小、杂质少、品质高并具有良好的耐酸碱性、耐温性及兼容性,达到了化妆品的使用标准,可作为保湿剂添加到化妆品中。

关键词: L-天冬氨酸, 聚天冬氨酸钠, 缩合聚合

Abstract: Cosmetic-grade sodium polyaspartate was synthesized through the polycondensation of L-aspartic acid. The effects of polymerization temperature, time and catalyst amount on the polymerization were systematically investigated to obtain the optimal polymerization conditions. The structure and molecular weight of sodium polyaspartate were characterized by nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (GPC). The properties of acid and alkali resistance, temperature resistance and compatibility were also evaluated. The resultant sodium polyaspartate has light color (white), low odor, few impurities and high quality, exhibits excellent acid, alkali, temperature resistance and compatibility, reaches the standard as a moisturizing additive.

Key words: L-aspartic acid, sodium polyaspartate, condensation polymerization

董怡麟, 张浩, 陈金龙. 化妆品级聚天冬氨酸钠的制备[J]. 应用化学, 2020, 37(8): 883-888.

DONG Yilin, ZHANG Hao, CHEN Jinlong. Preparation of Cosmetic-Grade Sodium Polyaspartate[J]. Chinese Journal of Applied Chemistry, 2020, 37(8): 883-888.

参考文献

[1] TAO Youhua. A New Method for Amino Acid Polymerization Based on Ring-Opening Polymerization of Lactam[J]. Acta Polym Sin,2016,9(9):1151-2259(in Chinese).
陶友华. 基于内酰胺开环聚合的氨基酸聚合新方法[J]. 高分子学报,2016,9(9):1151-2259.
[2] Tao Y H,Chen X Y,Jia F,et al. New Chemosynthetic Route to Linear ε-Poly-lysine[J]. Chem Sci,2015,7(6):6385-6391.
[3] Chen J L,Li M S,He W J. Facile Organocatalyzed Synthesis of Poly(ε-lysine) under Mild Conditions[J]. Macromolecules,2017,11(50):9128-9134.
[4] WANG Jiaming. Production,Application and Development Prospect of Polyaspartic Acid[J]. Chem Ind,2009,27(12):39-43(in Chinese).
汪家铭. 聚天冬氨酸生产应用与发展前景[J]. 化学工业,2009,27(12):39-43.
[5] Maninder K,Zhang H J,Martin L. Conjugates of Magnetic Nanoparticle-actinide Specific Chelatofor Radioactive Waste Separation[J]. Environ Sci Technol,2013,47(6):1142-1159.
[6] Kharecha P A,Hansen J E. Prevented Mortality and Greenhouse Gas Emissions from Historical and Projected Nuclear Power[J]. Environ Sci Technol,2013,47(15):4889-4895.
[7] He C J,Tian Z P,Zhang B R,et al. Inhibition Effect of Environment-friendly Inhibitors on the Corrosion of Carbon Steel in Recirculating Cooling Water[J]. Ind Eng Chem Res,2015,54(21):1971-1981.
[8] Comotti I M,Trueba M,Trasatti S P. The Pit Transition Potential in the Repassivation of Aluminium Alloys[J]. Surf Interface Anal,2013,45(21):1575-1583.
[9] Arutunow A,Darowicki K,Tobiszewski M T. Electrical Mapping of Aisi-304 Stainless Steel Subjected to Intergranular Corrosion Performed by Means of AFM-LIS in the Contact Mode[J]. Corros Sci,2013,71(6):37-44.
[10] Ma X. The Inhibition Effect of Polyaspartic Acid and Its Mixed Inhibitor on Mildsteel Corrosion in Seawater Wet/Dry Cyclic Conditions[J]. Int J Electrochem Sci,2016,10(2/4):3024-3038.
[11] Malcolm A. Effect of Various Cations on the Formation of Calciumcarbonate and Barium Sulfate Scale with and Without Scale Inhibitors[J]. Int J Electrochem Sci,2011,50(36):5852-5861.
[12] Hanson A D,Gregory J F. Folate Biosynthesis, Turnover and Transport in Plants[J]. Annu Rev Plant Biol,2010,62(24):105-125.
[13] Choudhury M R,Hsieh M K. Development of an Instantaneous Corrosion Rate Monitoring System for Metal and Metal Alloys in Recirculating Cooling Systems[J]. Ind Eng Chem Res,2012,51(2):4230-4236.
[14] Xu Y,Zhang B,Zhao L L,et al. Synthesis of Polyaspartic Acid/5-Aminoorotic Acid Graft Copolymer and Evaluation of Its Scale Inhibition and Corrosion Inhibition Performance[J]. Desalination,2013,311(6):156-161.
[15] DONG Ping,LI Xiaolin,QI Panlun. Progress in the Synthesis and Application of Polyaspartic Acid[J]. China Pet Chem Ind,2007,12(4):92-95(in Chinese).
董平,李晓琳,齐泮仑. 聚天冬氨酸的合成及应用进展[J]. 中国石油和化工,2007,12(4):92-95.
[16] Vegotsky A,Harada K,Fox S W. The Characterization of Polyaspartic Acid and Some Related Compounds 1,2[J]. J Am Chem Soc,1958,80(13):3361-3366.
[17] CAO Hui,SHANG Fei,TAN Tianwei. Synthesis of Polyaspartic Acid from Maleic Anhydride as Raw Material and Determination of Its Scale Inhibition Performance[J]. J Beijing Univ Chem Technol(Nat Sci Ed),2004,31(6):9-12(in Chinese).
曹辉,尚飞,谭天伟. 顺酐为原料合成聚天门冬氨酸及其阻垢性能的测定[J]. 北京化工大学学报(自然科学版),2004,31(6):9-12.
[18] Jacquet B,Papantoniou C,Land G. Polyaspartic Acid Derivatives, Their Preparation and Their Use in Cosmetic Composition:US,US4363797A[P]. 1982-12-14.
[19] Zuang V,Rona C,Distante F,et al. The Use of a Capacitance Device to Evaluate the Hydration of Human Skin[J]. J Appl Cosmetol,1997,9(15):95-102.
[20] LIU Haiyan,LV Aimin,LIU Shuping. Production Technology and Research Development of Polyaspartic Acid[J]. Hebei Chem Ind,2006,29(1):39-40(in Chinese).
刘海燕,吕爱敏,刘淑萍. 聚天冬氨酸的生产工艺及研究动态[J]. 河北化工,2006,29(1):39-40.
[21] Tomida M,Nakato T. Convenient Synthesis of High Molecular Weight Poly(succinimide) by Acid-catalyzed Polycondensation of L-Aspartic Acid[J]. Polymer,2010,38(18):4733-4736.
[22] Tomida M,Nakato T,Kuramochi M. Novel Method of Synthesizing Poly(succinimide) and Its Copolymeric Derivative by Acid-catalyzed Polycondensation of L-Aspartic Acid[J]. Polymer,2011,37(19):4435-4437.
[23] Koskan L P. Polyaspartic Acid as Calcium Sulfate and a Barium Sulfate Inbibitor[P]. US5116513.1992.