酚类衍生物的美白和抗氧化活性

doi:10.11944/j.issn.1000-0518.2019.11.190139

摘要/Abstract

摘要：

一系列酚类衍生物被合成,采用傅里叶变换红外光谱仪(FTIR)、核磁共振波谱仪(NMR)和电喷雾质谱(ESI-MS)等波谱技术对其进行了结构表征,并对其进行美白活性测试。结果表明,HB-1(0.229±0.026)、HB-3a(0.829±0.135)、HB-3b(0.446±0.047)、HMB-3a(1.747±0.215)、HMB-3b(1.307±0.058)和HPE-4b(2.501±0.261)对酪氨酸酶抑制作用明显优于阳性对照物α-熊果苷(3.60±0.029)。对显示出美白活性的化合物的抗氧化活性测试结果表明,HB-3b和HMB-3a抗氧化活性与阳性对照物槲皮素和番茄红素相当。因此该类化合物今后可作为美白剂和抗氧化剂加以开发利用。

关键词: 酚类化合物, 美白, 抗氧化

Abstract:

A series of phenolic derivatives was synthesized and characterized by Fourier transform infrared spectrometer(FTIR), nuclear magnetic resonance spectroscopy(NMR) and electrospray ionisation mass spectrometry(ESI-MS). Their whitening activity was also tested. The results showed that the tyrosinase inhibitory activities HB-1(0.229±0.026), HB-3a(0.829±0.135), HB-3b(0.446±0.047), HMB-3a(1.747±0.215), HMB-3b(1.307±0.058) and HPE-4b(2.501±0.261) were significantly better than those of the positive control, α-arbutin (3.60±0.029). The antioxidant activities of these compounds were tested to whitening potentials. The results showed that the antioxidant activities of HB-3b and HMB-3a were comparable to the positive control substance quercetin and lycopene. Therefore, such compounds can be developed and utilized as whitening agents and antioxidants.

Key words: penolic compounds, tyrosinase inhibitor, anti-oxidant

金宇婷, 支德福, 郭永泰, 隋悦, 孙蕾, 王倩, 赵龙铉, 赵春晖. 酚类衍生物的美白和抗氧化活性[J]. 应用化学, 2019, 36(11): 1257-1265.

JIN Yuting, ZHI Defu, GUO Yongtai, SUI Yue, SUN Lei, ZWANG Qian, HAO Longxuan, ZHAO Chunhui. Whitening and Antioxidant Activities of Phenolic Derivatives[J]. Chinese Journal of Applied Chemistry, 2019, 36(11): 1257-1265.

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