负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗

doi:10.11944/j.issn.1000-0518.2017.10.170049

摘要/Abstract

摘要：

为了探讨载有顺铂的温敏凝胶对小鼠宫颈癌的局部化疗作用,制备了载有顺铂的泊洛沙姆温敏凝胶,并通过流变学、体外溶蚀、体外释放等技术手段表征其结构和性能,采用鼠源宫颈癌U14细胞制备了原位宫颈/阴道癌模型,将载药凝胶灌注入荷瘤鼠阴道,评价载药凝胶对小鼠宫颈/阴道癌的抑制作用。结果表明,载有顺铂的泊洛沙姆温敏凝胶经阴道给药后对小鼠宫颈/阴道癌的抑瘤率可达到63.1%,可有效抑制小鼠宫颈癌的生长,而系统安全性则远远高于静脉注射顺铂。因此,载有顺铂的温敏凝胶有可能成为一种新型的宫颈癌治疗剂型。

关键词: 顺铂, 温敏凝胶, 宫颈癌, 泊洛沙姆

Abstract:

To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63.1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery via vagina against cervical cancer.

Key words: cisplatin, thermosensitive hydrogel, cervical cancer, poloxamer

王通, 柳时, 张秀英. 负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗[J]. 应用化学, 2017, 34(10): 1127-1133.

WANG Tong, LIU Shi, ZHANG Xiuying. Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice[J]. Chinese Journal of Applied Chemistry, 2017, 34(10): 1127-1133.

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