（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶的制备及其释药作用

doi:10.3724/SP.J.1095.2014.40072

摘要/Abstract

摘要： 将壳聚糖改性为（2-羟基-3-丁氧基）丙基羟丙基壳聚糖（2-H-3-B-P-HPCS），并以（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖和聚乙二醇（PEG）为原料制备（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶，研究了（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖浓度、聚乙二醇的用量、交联剂戊二醛用量、反应温度对该凝胶溶胀性能的影响。通过红外光谱分析和扫描电子显微镜的方法比较了壳聚糖、（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖和（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶结构和形态上的不同。以阿昔洛韦为模型药物研究了其释药性能。结果表明，该凝胶均具有良好的溶胀性、pH敏感性和药物缓释作用，有望用作新型的药物载体。

关键词: (羟基丁氧基)丙基-羟丙基壳聚糖, 聚乙二醇, 凝胶, 释药

Abstract: (2-Hydroxy-3-butoxy)propyl hydroxypropyl chitosan (2-H-3-B-P-HPCS) was synthesized to prepare 2-H-3-B-P-HPCS/polyethylene glycol (2-H-3-B-P-HPCS/PEG) interpenetrating polymer network(IPN) hydrogels. The factors that could influence swelling properties of 2-H-3-B-P-HPCS/PEG IPN hydrogels were studied, such as concentration of 2-H-3-B-P-HPCS, reaction temperature， amount of PEG and glutaral. The 2-H-3-B-P-HPCS/PEG IPN hydrogels were investigated by SEM and IR. Aciclovir as a model drug was used to study the release performance. The results show that 2-H-3-B-P-HPCS/PEG IPN hydrogels have good swelling property, pH sensibility and drug releasing ability and can be used for a new drug carrier.

Key words: (hydroxy-butoxy)propyl-hydroxypropyl chitosan, polyethylene glycol, hydrogel, drug release

中图分类号:

O635

谭福能, 何媛媛, 隋卫平. （2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶的制备及其释药作用[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.40072.

TAN Funeng1*, HE Yuanyuan2, SUI Weiping3. Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.40072.

参考文献

[1] YAND Xudong,WU Guojie,LIN Wanjin. Preparation and Properties of Chitosan Hydrogel[J]. New Chem Mater,2005,33(12):48-50(in Chinese).

杨旭东,吴国杰,林玩金. 壳聚糖水凝胶的制备及性能研究[J]. 化工新型材料,2005,33(12):48-50.

[2] Risbud M V,Hardikar A A,Bhat S V,et al. pH Sensitive Freeze-Dried Chitosan Polyvinyl Pyrrolidone Hydrogels as Controlled Release System for Antibiotic Delivery[J]. J Controlled Release,2000,68:23-30.

[3] Martin L,Wilsona C G,Fariba K,et al. Sustained Buccal Delivery of the Hydrophobic Drug Denbufylline Using Physically Cross-Linked Palmitoyl Glycol Chitosan Hydrogels[J]. Eur J Pharm Biopharm,2003,55:35-45.

[4] Lin Y H,Liang H F,Chung C K,et al. A Non-covalently Cross-linked Chitosan Based Hydrogel [J]. Biomaterials,2005,26:2105-2113.

[5] Montembault A,Viton C,Domard A,et al. Rheometric Study of the Gelation of Chitosan in a Hydroalcoholic Medium[J]. Biomaterials,2005,26:1633-1643.

[6] Majeti N V,Ravi K. A Review of Chitin and Chitosan Applications[J]. React Funct Polym,2000,46(1):1-27.

[7] Campos J B,Lourencao B C,Omuro Lupetti K,et al. Development of a Method Employing Chitosan to Remove Metallic Ions from Wastewater[J]. Quim Nova,2007,30(4):879-884.

[8] SHI Yidong,JI Li,CHEN Yanxia,et al. Study on the Properties of Water-soluble Hydroxypropyl Chitosan[J]. J Sichuan Univ(Eng Sci Edit),2006,38(3):100-104(in Chinese).

施亦东,季莉,陈衍夏,等. 水溶性羟丙基壳聚糖的性能研究[J]. 四川大学学报:工程科学版,2006,38(3):100-104.

[9] Noble L,Gray A I,Sadiq L,et al. A Non-covalently Cross-linked Chitosan Based Hydrogel[J]. Int J Pharm,1999,192:173-182.

[10] Martin L,Wilson C G,Koosha F,et al. The Release of Model Macromolecules may be Controlled by the Hydrophobicity of Palmitoyl Glycol Chitosan Hydrogels[J]. J Controlled Release,2002,80(3):87-100.

[11] Uchegbu I F,Schatzlein A G,Tetley L,et al. Polymeric chitosan-based Vesicles for Drug Delivery[J]. J Pharm Pharmacol,1998,50:453-458.

[12] Ruel E G,Leclair G,Hildgen P,et al. Thermosensitive Chitosan-based Hydrogel Containing Liposomes for the Delivery of Hydrophilic Molecules[J]. J Controlled Release,2002,82:373-383.

[1]	李玉凰, 卢泽毅, 袁红梅, 王刚, 张成江. 酰腙键聚合物凝胶的制备及其在硝基呋喃类药物分析中的应用[J]. 应用化学, 2023, 40(1): 100-108.
[2]	姚競, 戴明明. 基于乘用车轮胎胎面胶粉的再生橡胶的制备及性能[J]. 应用化学, 2023, 40(1): 52-58.
[3]	黄旭娟, 王婷, 丁正青, 杨欣欣, 蔡照胜, 商士斌. 脱氢枞氧基聚氧乙烯缩水甘油醚接枝羟乙基壳聚糖水凝胶制备及其性能[J]. 应用化学, 2022, 39(9): 1421-1428.
[4]	王凯, 杨海宽, 刘慧兰, 路嘉敏, 张晨. 基于豆甾醇衍生物的超分子凝胶的合成与性能[J]. 应用化学, 2022, 39(9): 1453-1463.
[5]	李德, 王楠, 杨华伟, 马姣. 液态金属原位引发制备半互穿网络水凝胶构建低污染电化学传感界面[J]. 应用化学, 2022, 39(9): 1464-1474.
[6]	张万年, 于芳, 赵杉林, 张志强, 何宇鹏. 小分子凝胶的分子动力学模拟和汉森溶解度参数研究进展[J]. 应用化学, 2022, 39(12): 1803-1817.
[7]	袁定坤, 褚维凡, 倪加惠. 亚铁氰化铜-聚丙烯酰胺/羧甲基纤维素/石墨烯复合水凝胶的制备及铷吸附性能[J]. 应用化学, 2022, 39(11): 1746-1756.
[8]	赵常利, 秦明高, 窦晓秋, 冯传良. 纳米颗粒增强的手性超分子水凝胶成骨性能[J]. 应用化学, 2022, 39(1): 177-187.
[9]	刘旭, 李杨可欣, 杜黎, 于健, 王佳程, 耿阳, 韩广, 孙宽, 李猛. 水凝胶的制备及仿生设计在能源领域应用的研究进展[J]. 应用化学, 2022, 39(1): 35-54.
[10]	李胜男, 付俊. 水凝胶仿生柔性电子学[J]. 应用化学, 2022, 39(1): 55-73.
[11]	唐立宗, 张琳, 董云生, 齐春晓, 刘祥胜, 王淑芳. 响应性水凝胶及其在生物医药领域应用研究进展[J]. 应用化学, 2021, 38(7): 743-753.
[12]	张进科, 苟利鹏, 张满, 王国丞, 杨金峰, 杜娟, 刘平礼. 一种油井堵水控水自修复水凝胶[J]. 应用化学, 2021, 38(7): 807-815.
[13]	马庆华, 朱向国, 郑佳, 刘刚, 杜琳. 凝胶排阻色谱-多角度激光散射法测定破伤风类毒素相对分子质量分布[J]. 应用化学, 2021, 38(6): 739-742.
[14]	高峰, 徐子迪, 管纯倩, 王研, 臧云浩, 顾建峰, 曲江英. 硫/石墨烯气凝胶的绿色可控制备及锂硫电池性能[J]. 应用化学, 2021, 38(4): 439-446.
[15]	牛贺强, 武发思, 王丽琴, 樊再轩. 凝胶材料在文物表面污渍去除中的研究进展[J]. 应用化学, 2021, 38(11): 1441-1453.