二氯乙酸钠电纺纤维毡改善宫颈癌小鼠生存质量

doi:10.3724/SP.J.1095.2014.30537

摘要/Abstract

摘要： 通过溶液静电纺丝的方法，将水溶性药物二氯乙酸钠(DCA)包裹入油溶性聚乳酸(PLA)中，制备出二氯乙酸钠电纺纤维毡。将其应用于宫颈癌的活体实验中，结果表明在为期19 d的治疗下，荷瘤小鼠的肿瘤抑制率达到94%，总体康复率达到38%。同时，DCA电纺纤维毡还极大地抑制了宫颈癌后期复发和转移的趋势，提高了荷瘤小鼠的生存质量，是一种安全且疗效确切的抗癌给药剂型。

关键词: 宫颈癌, 二氯乙酸钠, 静电纺丝, 生存质量

Abstract: Solidum dichloroacetate(DCA) loaded electrospun mats was fabricated through the solution electrospun method. When applying this DCA-loaded electrospun mats on the therapy of the subcutaneous cervical cancer model, a 94% tumor suppression rate and an overall 38% recovery rate were achieved after 19 days' treatment. The trend of recurrence and metastasis was also significantly inhabited. Meanwhile, DCA-loaded electropsun mats improved the life quality of tumor-bearing mice fundamentally. Therefore, DCA administrated by electrospun mats is a safe approach for the treatment of anti-cervical cancer.

Key words: cervical cancer, sodium dichloroacetate, electropsun mats, suvivial quality

中图分类号:

O615.4

刘大兴, 王明哲, 景遐斌, 黄宇彬. 二氯乙酸钠电纺纤维毡改善宫颈癌小鼠生存质量[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30537.

LIU Daxing1,2, WANG Mingzhe1, JING Xiabin1, HUANG Yubin1*. Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetate-loaded Electrospun Mats[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30537.

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