2-呋喃甲酰腙衍生物的合成、荧光性质及抑菌活性

doi:10.3724/SP.J.1095.2014.30454

摘要/Abstract

摘要： 以2-呋喃甲醛、苯甲酰肼及其衍生物为原料，合成了4个新型呋喃酰腙（4a~4d），用溶剂挥发法获得了酰腙4a的单晶，并用X射线单晶衍射仪测定了晶体和分子结构。通过元素分析、核磁共振、红外光谱、紫外光谱和荧光光谱等技术手段对酰腙（4a~4d）进行了表征。结构分析表明，酰腙4a通过分子间氢键和分子间呋喃环错位面对面π…π作用力构成二维链式层状结构；荧光分析表明，酰腙4c拥有较强的荧光发射。采用琼脂扩散法测试了酰腙（4a~4d）对大肠杆菌、金黄色葡萄球菌、绿脓杆菌的抑制活性，结果显示，酰腙4c对金黄色葡萄球菌有显著的抑制活性。

关键词: 呋喃酰腙, 晶体结构, 荧光性, 抑菌活性

Abstract: Four furan acylhydrazones derivatives(4a~4d) were synthesized from 2-furancarbaldehyde and benzohydrazide derivatives and characterized by using elemental analysis, 1H NMR, FT-IR,UV and fluorescence spectroscopy methods. The results show that the 2D chain layered structure was assembled through intermolecular hydrogen bonds and face to face π…π stacking interactions of the furan rings. The single crystal of acylhydrazone 4a was obtained through the solvent evaporation method. Its crystal and molecular structures were determined through X-ray scattering. Fluorescence test shows that the acylhydrazone 4c has strong fluorescence. All furan acylhydrazones were screened for their antibacterial activities to Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa by agar diffusion method. The result shows that acylhydrazone 4c has very significant antibacterial activity to Staphylococcus aureus. CCDC:947253

Key words: furan acylhydrazone, crystal structure, luminescence property, antibacterial activity

中图分类号:

O626

宋斌, 郑长征, 张铭凯, 徐守卫, 任立娣. 2-呋喃甲酰腙衍生物的合成、荧光性质及抑菌活性[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30454.

SONG Bin1, ZHENG Changzheng1*, ZHANG Mingkai2, XU Shouwei1, REN Lidi1. Synthesis, Luminescence Property and Antibacterial Activities of 2-Furoylhydrazone Derivatives[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30454.

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