应用化学

• 研究简报 • 上一篇    

吡啶-2-甲酸锰(Ⅱ)配合物催化环氧化合成氟环唑的绿色方法

孟志,褚岩凤,姜鹏*   

  1. (沈阳化工研究院有限公司,新农药创制与开发国家重点实验室 沈阳 110021)
  • 收稿日期:2013-01-29 修回日期:2013-03-31 出版日期:2014-01-10 发布日期:2014-01-10
  • 通讯作者: 姜鹏,教授级高工; Tel:024-85869280; E-mail:jiangpeng@sinochem.com; 研究方向:手性农药的合成
  • 基金资助:
    国家“十二五”科技支撑计划项目(2011BAE06B00),国家重点基础研究发展计划(973计划)项目(2010CB735601)

A Green Synthetic Method to Epoxiconazole Catalyzed by Pyridine-2-carboxylic Acid Manganese(Ⅱ) Complex

MENG Zhi, CHU Yanfeng, JIANG Peng*   

  1. (State Key Laboratory of the Discovery and Development of Novel Pesticide,
    Shenyang Research Institute of Chemical Industry Co.,Ltd.,Shenyang 110021,China)
  • Received:2013-01-29 Revised:2013-03-31 Published:2014-01-10 Online:2014-01-10
  • Contact: jiang

摘要: 以吡啶-2-甲酸锰(Ⅱ)配合物为催化剂,质量分数30%的双氧水为氧源,催化氧化(Z)-3-(1H-1,2,4-三氮唑)-2-(4-氟苯基)-1-(2-氯苯基)丙烯合成了氟环唑,其环氧化收率高达80%以上。 该体系具有潜在的工业前景。

关键词: 吡啶甲酸锰(Ⅱ)配合物, 环氧化, 氟环唑

Abstract: An efficient and facile procedure for the synthesis of epoxiconazole from (Z)-3-(1H-1,2,4-triazole)-2-(4-fluorophenyl)-1-(2-chlorophenyl)propene was reported. An overall yield up to 80% can be achieved in the presence of pyridine-2-carboxylic acid manganese(Ⅱ) complex as catalyst and 30% mass fraction of hydrogen peroxide as terminal oxidant. This process has the potential for industrial scale up.

Key words: pyridine-carboxylic acid manganese(Ⅱ) complex, epoxidation, epoxiconazole

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