关键词: 氯丙胺盐酸盐, N-（氨基丙基）甲基丙烯酰胺盐酸盐, 工艺改进

Abstract: A new method to prepare N-(3-aminopropyl) methacrylamide hydrochloride(Ⅴ) was introduced. N-(3-Chloropropyl) methacrylamide(Ⅱ), obtained by acylation reaction between 3-chloropropylamine-hydrochloride(Ⅰ) and methacrylic anhydride, was transformed via Gabriel method to N-[N′-(methacryl)-3-aminopropyl] phthalimide(Ⅲ) and hydrazinolysis product N-(3-aminopropyl) methacrylamide(Ⅳ) and then hydrochloric acidification to compound Ⅴ. The overall yield of the reaction is about 61.1%. This process does not need to use any expensive amino protection reagent, which can dramatically reduces the cost of raw materials.

Key words: chloropropylamine hydrochloride, N-(aminopropyl)methacrylamide hydrochloride, process improvement