中华医学超声杂志

应用化学 ›› 1994, Vol. 0 ›› Issue (5): 98-100.

• 研究论文 • 上一篇    下一篇

油酰丝裂霉素及其脂质体的合成与抗肿瘤活性

吴道澄1, 徐梁2, 张学庸2   

  1. 1. 第四军医大学化学教研室 西安 710032;
    2. 第四军医大学西京医院全军消化病专科中心 西安
  • 收稿日期:1994-01-03 修回日期:1994-05-04 出版日期:1994-10-10 发布日期:1994-10-10

Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity

Wu Daocheng1, Xu Liang2, Zhang Xueyong2   

  1. 1. Department of Chemistry, The Fourth Military Medical Universily, Xi'an710032;
    2. Center of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, Xi'an
  • Received:1994-01-03 Revised:1994-05-04 Published:1994-10-10 Online:1994-10-10

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摘要： 用油酸与丝裂霉素C在缩合剂存在下合成了油酰丝裂霉素C,利用元素分析、红外光谱及核磁共振等确定其结构。用改良的逆相蒸发法制成了油酰丝裂霉素C脂质体,动物实验表明该脂质体抗肿瘤效果为游离丝裂霉素C的2.2倍,而毒性仅为游离丝裂霉素的1/20。

关键词: 油酰丝裂霉素, 脂质体, 抗肿瘤活性

Abstract: The oleoyl mitomycin C was synthesized by reacting mitomycin C with oleic acid.Its structure was determined by elementary analysis,1H NMR spectra and IR spectra. The liposome of oleoyl mitomycin was prepared by a modified reverse-phase evaporation method.The antitumor assay on mice indicated that this liposome showed 2.2 times more powerful cytotoxicity to human gastric cancer cell line than MMC and very low cytotoxicity to normal human embryonic lung cell line.

Key words: oleoyl mitomycin C, liposome, antitumor activity

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