微波辅助铜合成2-(N,N-二甲氨基)苯并噁唑衍生物

doi:10.11944/j.issn.1000-0518.2019.02.180094

摘要/Abstract

摘要：

建立了一种简单实用、经济高效的以取代2-碘芳胺和N,N-二甲基氨基硫代甲酰氯为原料,以碘化亚铜为催化剂,吡啶为溶剂,100 ℃条件下,串联合成2-(N,N-二甲氨基)苯并噁唑衍生物的微波催化体系,合成了一系列中等至良好产率的2-(N,N-二甲氨基)苯并噁唑衍生物,最高产率达90%。

关键词: 微波辅助合成, 2-(N,N-二甲氨基)苯并噁唑, 碘化亚铜

Abstract:

Microwave-assisted one-pot synthesis of a variety of N,N-dimethyl-2-benzoxazolamine derivatives were achieved by the cascade reaction of substituted 2-iodoanilines with dimethylcarbamothioic chloride in pyridine in the presence of CuI at 100 ℃ with moderate to good yields(up to 90%).

Key words: microwave-assisted synthesis, N,N-dimethyl-2-benzoxazolamines, 2-iodoanilines

林晨,林小燕,张鹏,许贻文,许建华,柯方. 微波辅助铜合成2-(N,N-二甲氨基)苯并噁唑衍生物[J]. 应用化学, 2019, 36(2): 182-187.

LIN Chen,LIN Xiaoyan,ZHANG Peng,XU Yiwen,XU Jianhua,KE Fang. Copper-catalyzed Microwave-Assisted Synthesis of N,N-Dimethyl-2-benzoxazolamine Derivatives[J]. Chinese Journal of Applied Chemistry, 2019, 36(2): 182-187.

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