卵磷脂类液晶乳液的性能

doi:10.11944/j.issn.1000-0518.2018.10.170333

摘要/Abstract

摘要：

以卵磷脂为主乳化剂制备了一款液晶乳液。该乳液在皮肤上具有良好的稳定性能,在皮肤表层停留6 h仍能保持完整的液晶结构,克服了一般液晶乳液中液晶织构无法在皮肤上长时间停留的问题。液晶结构在皮肤温度范围内具有较高的稳定性,可为液晶乳液其他性能的发挥提供条件。基于此,我们采用体外称重法研究了液晶乳液的锁水性,发现液晶乳液锁水性能明显优于传统乳液,实验7 h后仍能保持原有水分总质量的50%;体外透析实验证实,液晶乳液表现出显著的缓释性能且能释放完全,7 h后目标分子(水杨酸钠)释放率可达96%;耐温性能研究表明,液晶乳液耐高温性能及低温冻融性能优良,且温度对乳液中层状液晶的影响是可恢复的;采用离心法、高低温循环和高低温长时间(3个月)放置的方法探究了乳液储运稳定性,结果表明,液晶乳液产品储运稳定性极佳,便于实际的应用和储运。该研究不仅可为开发多效的高端化妆品提供必要信息和参考数据,而且有望拓展卵磷脂类液晶乳化剂体系的应用范畴。

关键词: 卵磷脂类乳化剂, 层状液晶, 乳液性能, 护肤乳液

Abstract:

A kind of liquid crystal emulsion was prepared with lecithin as the main emulsifier. The emulsion has good stability on the skin. The whole liquid crystal structure can be maintained for 6 hours on the surface of skin. It overcomes the problem that liquid crystal texture cannot stay on the skin for a long time in general liquid crystal emulsion. Liquid crystal structure has a high stability near skin temperature. It can provide conditions for other performances of liquid crystal emulsion. The water locking properties of different emulsions are measured by in vitro weighing method and the water locking property of liquid crystal emulsion is better than that of traditional emulsion. There are still fifty percent of the total water contents after 7 h. The results of dialysis experiments in vitro confirm that the liquid crystal emulsion has a remarkable slow-release property and can be released completely. The release ratio of target molecule is up to 96% after 7 h. It also shows that liquid crystal emulsion has excellent temperature resistance and low temperature freeze-thaw properties. The effect of temperature on the lamellar liquid crystals in emulsion is recoverable. The storage and transportation stability of emulsion is studied by the centrifugal method, high and low temperature cycle and placement under high and low temperature for 3 months. It shows that liquid crystal emulsion products have excellent storage and transportation stability. It is convenient for practical application and storage and transportation. The study not only provides necessary information and reference data for the development of multi-effect upmarket cosmetics, but also expands the application category of lecithin liquid crystal emulsifier system.

Key words: lecithin emulsifier, lamellar liquid crystals, emulsion properties, skin care emulsions

周梦, 舒鹏, 冯蓓, 尚亚卓, 刘洪来, 李成亮. 卵磷脂类液晶乳液的性能[J]. 应用化学, 2018, 35(10): 1227-1233.

ZHOU Meng, SHU Peng, FENG Bei, SHANG Yazhuo, LIU Honglai, LI Chengliang. Properties of Lecithin Liquid Crystal Emulsion[J]. Chinese Journal of Applied Chemistry, 2018, 35(10): 1227-1233.

参考文献

[1]	WANG Liangyu,LIAO Songsheng. Liquid Crystal Chemistry[M]. Bejing:Science Press,1988(in Chinese). 王良御,廖松生. 液晶化学[M]. 北京:科学出版社,1988.
[2]	JIA Bing,ZHANG Wanping,CHEN Minghua.Research Progress in Liquid Crystal Structure and the Application in Cosmetics[J]. Deterg Cosmet,2015,38(12):21-26(in Chinese). 贾兵,张婉萍,陈明华. 液晶结构及其在化妆品中的应用研究进展[J]. 日用化学品科学,2015,38(12):21-26.
[3]	Tsai C,Lin L H,Kwan C C.Surface Properties and Morphologies of Pheohydrane/Liquid Crystal Moisturizer Product[J]. Int J Cosmet Sci,2010,32(4):258-265.
[4]	Ghosh S,Rousseau D.Fat Crystals and Water-in-oil Emulsion Stability[J]. Curr Opin Colloid Interface Sci,2011,16(5):421-431.
[5]	Otto A.Formulation Effects of Topical Emulsions on Transdermal and Dermal Delivery[J]. Int J Cosmet Sci,2009,31(1):1-19.
[6]	WANG Zhongni,ZHAO Jing,ZHOU Wu,et al. Rheological Properties and Drug Release Behavior of the Lamellar Liquid Crystals[J]. Food Drug,2011,13(5):157-161(in Chinese). 王仲妮,赵静,周武,等. 层状液晶的流变性质和释药行为研究[J]. 食品与药品,2011,13(5):157-161.
[7]	Kim I Y,Nakagawa S,Ri K,et al. Liquid Crystal O/W Emulsions to Mimic Lipids and Strength Skin Barrier Function[J]. Cosmet Toilet,2009,124(6):64-72.
[8]	LI Xuejing,Olga Gey,Christian Quellet,et al. Influence of Process Parameters on Structure of Lamellar Liquid Crystal Emulsions[J]. China Surfactant Deterg Cosmet,2006,36(3):143-147(in Chinese). 李学静,Olga Gey,Christian Quellet,等. 工艺参数对层状液晶乳液结构的影响[J]. 日用化学工业,2006,36(3):143-147.
[9]	LI Chunlei.Study and Preparation of Lamellar Liquid Crystal Type Skin Care Emulsions[D]. Guangzhou:South China University of Technology,2014(in Chinese). 李春蕾. 层状液晶型护肤乳液的研究与制备[D]. 广州:华南理工大学,2014.
[10]	YUAN Minjia,WANG Fei,ZHANG Lihua,et al. Influence of Formulation Ingredients and Physicochemical Environment on Formation of Liquid Crystal in Alkyl Polyglucoside System[J]. China Surfactant Deterg Cosmet,2016,16(2):84-88(in Chinese). 袁旻嘉,汪飞,章丽华,等. 配方组成及物化环境对烷基糖苷乳化体系液晶形成的影响[J]. 日用化学工业,2016,16(2):84-88.
[11]	ZHANG Wanping,ZHU Liangliang.Effect of Femulsification Technology in Formation of Liquid Crystals[J]. China Surfactant Deterg Cosmet,2009,39(1):35-38(in Chinese). 张婉萍,朱亮亮. 乳化工艺对液晶形成的影响研究[J]. 日用化学工业,2009,39(1):35-38.
[12]	SHEN Xiaoqin,FANG Yun,LU Jie,et al. Influence of Co-emulsifier on Stability and Liquid Crystal Status of Cosmetic Emulsion[J]. China Surfactant Deterg Cosmet,2002,32(1):8-11(in Chinese). 沈晓勤,方云,陆婕,等. 助乳化剂对化妆品乳液稳定性和液晶性的影响[J]. 日用化学工业,2002,32(1):8-11.
[13]	LIU Chunjuan,LI Jun,LIANG Qing,et al. Study on Preparation and Properties of Oviductus ranae Moisturizing Emulsions[J]. Food Ind,2017,38(1):95-98(in Chinese). 刘春娟,李军,梁青,等. 林蛙油保湿乳液的制备及其性能研究[J]. 食品工业,2017,38(1):95-98.
[14]	CAI Li,WANG Fuping.Study on the Feasibility of Evaluating Drug in vitro Sustained Release Performance by Overflow Dissolution Method[J]. China Pharm,2017,28(13):1827-1830(in Chinese). 蔡丽,王富平. 溢流式溶出法评价药物体外缓释性能的可行性研究[J]. 中国药房,2017,28(13):1827-1830.
[15]	Feng G L,Xiong Y,Wang H,et al. Gelation of Microemulsions and Release Behavior of Sodium Salicylate from Gelled Microemulsions[J]. Eur J Pharm Biopharm,2009,71(2):297-302.
[16]	JIAN Junli,MAO Lijuan,LIU Fuguo,et al. Advances in Freeze-thaw Stability of Food Emulsion Research[J]. Food Ferment Ind,2015,41(4):236-240(in Chinese). 简俊丽,毛丽娟,刘夫国,等. 食品乳状液冻融稳定性的研究进展[J]. 食品与发酵工业,2015,41(4):236-240.
[17]	Wang L L,Xiong Y L.Inhibition of Lipid Oxidation in Cooked Beef Patties by Hydrolyzed Potato Protein is Related to Its Reducing and Radical Scavenging Ability[J]. J Agric Food Chem,2005,53(23):9186-9192.