二苯羧酸类稀土配合物对藤黄微球菌抑制作用的微量热研究

doi:10.11944/j.issn.1000-0518.2017.05.160296

摘要/Abstract

摘要：

合成了4例二苯羧酸类稀土配合物:[Re₂(oba)₃(H₂O)₅]·H₂O[Re=La(1)、Ce(2)、Sm(3)、Er(4)](oba=4,4'-二羧基二苯基醚),利用元素分析、红外光谱和粉末X射线衍射等技术手段对其结构及组成进行了表征,热重分析表明,4例配合物具有良好的热稳定性。采用微量热法,实时跟踪监测4种目标配合物对藤黄微球菌的抑制作用,得到了热谱曲线。依据热动力学模型对热谱曲线进行解析,计算了生长和抑制过程的热动力学函数,在不同浓度配合物存在时,获得了细菌生长速率常数(k)、最大产热功率(P_max)、传代时间(t_G)以及抑制率(I)等参数。结果表明,4种配合物对藤黄微球菌均具有抑制作用,抑菌效果依次为:[Er₂(oba)₃(H₂O)₅]·H₂O(4)>[Sm₂(oba)₃(H₂O)₅]·H₂O(3)>[Ce₂(oba)₃(H₂O)₅]·H₂O(2)>[La₂(oba)₃(H₂O)₅]·H₂O(1)。

关键词: 稀土羧酸配合物, 微量热学, 藤黄微球菌, 热动力学

Abstract:

Four isostructural rare earth complexes, namely [Re₂(oba)₃(H₂O)₅]·H₂O[Re=La(1), Ce(2), Sm(3), Er(4), H₂oba=4,4'-oxybisbenzoic acid], have been synthesized under solvothermal conditions and characterized by elemental analysis, infrared(IR) spectrometry, and powder X-ray diffraction. Thermogravimetric analysis demonstrates that these complexes possess good thermostability. Micrococcus luteus inhibition by these complexes have been real-time detected by means of microcalorimetry. The growth rate constant k, maximum power P_max, passage time t_G and inhibitive ratio I, respectively, have been obtained. Experimental results indicate that the title complexes present effective inhibition on Micrococcus luteus, and the order is listed as follows:[Er₂(oba)₃(H₂O)₅]·H₂O(4)>[Sm₂(oba)₃(H₂O)₅]·H₂O(3)>[Ce₂(oba)₃(H₂O)₅]·H₂O(2)>[La₂(oba)₃(H₂O)₅]·H₂O(1).

Key words: rare earth carboxylic complexes, microcalorimetry, Micrococcus luteus, thermodynamics

岑培培, 何艳萍, 李菲菲, 曹良, 陈小燕, 宋伟明. 二苯羧酸类稀土配合物对藤黄微球菌抑制作用的微量热研究[J]. 应用化学, 2017, 34(5): 582-589.

CEN Peipei, HE Yanping, LI Feifei, CAO Liang, CHEN Xiaoyan, SONG Weiming. Microcalorimetric Study of Micrococcus Luteus Inhibition by Rare Earth Complexes with Carboxylate Ligand[J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 582-589.

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