酸化蒙脱土/氯化锌催化叔丁醚和叔丁酯的合成

doi:10.11944/j.issn.1000-0518.2016.05.150318

摘要/Abstract

摘要：

以酸化蒙脱土/氯化锌作为催化剂,二碳酸二叔丁酯与一系列酚、醇和羧酸类化合物在120 ℃封管条件下反应,合成了叔丁醚和叔丁酯类衍生物,方法简单,经济可靠,环境友好,后处理方便,收率为61%~75%,产物结构经¹H NMR,ESI-MS确证。探讨了溶剂、温度、金属离子等因素对反应收率的影响,并提出了可能的反应机理。为今后该类化合物的合成提供了一种新的方法。

关键词: 酸化蒙脱土, 氯化锌, 叔丁酯, 叔丁醚, 有机合成

Abstract:

With acid-treated montmorillonite supported zinc chloride(H-mont/ZnCl₂) as the catalyst, phenols, alcohols, and carboxylic acid were reacted with di-tert-butyl dicarbonate to give tert-butyl ether and tert-butyl ester derivatives at 120 ℃ in sealed tube with yields ranging from 61% to 75%, which is simple and environmentally friendly. All the compounds synthesized were confirmed by ¹H NMR and ESI-MS. The effect of solvent, temperature, metal ion and some other factors to the reaction were investigated. A possible mechanism for this reaction was proposed. Provided a new method for this type of synthesis in the future.

Key words: acid-treated montmorillonite, zinc chloride, tert-butyl ethers, tert-butyl esters, organic synthesis

吴剑虹, 陈冬寅, 李飞. 酸化蒙脱土/氯化锌催化叔丁醚和叔丁酯的合成[J]. 应用化学, 2016, 33(5): 565-570.

WU Jianhong, CHEN Dongyin, LI Fei. Synthesis of tert-Butyl Ethers and tert-Butyl Esters Catalyzed by Acid-treated Montmorillonite Supported Zinc Chloride[J]. Chinese Journal of Applied Chemistry, 2016, 33(5): 565-570.

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