中华医学超声杂志

应用化学 ›› 2009, Vol. 26 ›› Issue (09): 1126-1128.

• 研究简报 • 上一篇    

离子液体中卤素交换氟化合成七氟醚

李斌栋*,吕春绪   

  1. (南京理工大学化工学院 南京 210094)
  • 收稿日期:2008-07-04 修回日期:2008-12-12 出版日期:2009-09-10 发布日期:2009-09-10
  • 通讯作者: 李斌栋,男，博士，讲师; E-mail:henrylbd@sina.com; 研究方向：有机合成与应用

Synthesis of sevoflurane changed by halogen-exchange fluorination in Ionic Liquids

LI Bin-Dong*,LV Chun-Xu   

  1. (College of Chemical Engineering,Nanjing University of Science & Technology,Nanjing 210094)
  • Received:2008-07-04 Revised:2008-12-12 Published:2009-09-10 Online:2009-09-10

PDF

11844

被引次数

8 | 1

摘要：

在离子液体作为反应介质的条件下,以六氟异丙基氯甲基醚的氟代反应合成了七氟醚。 探讨了氟代反应机理,考察了[bpy]BF4、[bmim]BF4、[bepy]BF4、[bmim]PF6对反应产率的影响，研究了氟化剂、水和温度对反应产率的影响。 结果表明,以[bepy]BF4为反应介质,高比表面积的KF和微量的水有利于固态KF的部分离解进入有机相形成高活性的F-从而减少副产物,收率达到94.6%。 离子液体可重复使用3次以上，其活性没有明显下降。

关键词: 离子液体中卤素交换氟化合成七氟醚

Abstract:

Sevoflurane was synthesized from 1,1,13,3,3-hexafluoro-2-(chloromethoxy)-propane by halogen-exchange in the presence of an ionic liquid as the solvent and a fluorinating agent . Mechanism of the phase transfer catalysis was discussed. The effects of [bpy]BF4, [bmim]BF4, [bepy]BF4 and [bmim]PF6 on the yield were investigated. The ionic liquidwater system and high surface area could not only induce KF to enter into the ionic liquid to produce high active F- but also reduce the formation of byproducts. The yield was 94.6％. The ionic liquid could be reused for three times without noticeable loss of activity.

Key words: ionic liquid,sevoflurane,synthesis,potassium fluoride

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