中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (3): 53-57.

• 研究论文 • 上一篇    下一篇

氯氮平的吸附伏安行为

曾泳淮, 马红艳   

  1. 北京师范大学化学系, 北京 100875
  • 收稿日期:1996-08-25 修回日期:1997-03-28 出版日期:1997-06-10 发布日期:1997-06-10

Adsorptive Voltammetric Behavior of Clozapine

Zeng Yonghuai, Ma Hongyan   

  1. Department of Chemistry, Beijing Normal University, Beijing 100875
  • Received:1996-08-25 Revised:1997-03-28 Published:1997-06-10 Online:1997-06-10

PDF

465

被引次数

1

摘要： 在0.1mol/LNH4Ac(pH7.8)底液中,氯氮平(CLP)在汞电极上有一线性扫描还原峰,Epc=-1.34V(vs.Ag/AgCl).该峰具有明显的吸附性,吸附粒子为CLP中性分子。测得CLP在汞电极上的饱和吸附量为2.7×10-10mol/cm2,每个CLP分子所占电极面积为0.62nm2,CLP在悬汞电极上的吸附符合Frumkin等温式。测得吸附系数β=6.28×105,吸引因素γ=0.75,电子转移数n为2,不可逆吸附的转移系数α为0.53.探讨了CLP在汞电极上的还原机理,并建立了吸附溶出伏安法测定CLP的最佳条件,检测限为8.0×10-9mol/L.

关键词: 氯氮平, 吸附伏安法, 电化学行为

Abstract: In a supporting electrolyte containing 0.1 mol/L NH4Ac(pH 7.8), a reduction peak of clozapine(CLP)was found by linear-sweep voltammetry at Hg electrode. The peak shows a potential of-1.34 V(vs.Ag/AgCl)and adsorptive characteristics. When the concentration of CLP is sufficiently low, the sweep rate is sufficiently rapid and the accumulation time is sufficiently long, the peak current is totally contributed by the reduction of the adsorbed CLP. The adsorbed species is most probably neutral molecules of CLP. The saturated adsorption amount of CLP at Hg electrode is 2.7?10-10 mol/cm2 and every CLP molecule occupies 0.62 nm2. On the surface of HMDE, the adsorption of CLP obeys Frumkin adsorption isotherm. The adsorption coefficient is 6.28?105, the attractive factor is 0.75. The number of electrons transferred per CLP molecule, n, is 2 and the transfer coefficient of the irreversible adsorptive system of CLP is 0.53. The mechanism of electrochemical reduction of CLP at Hg electrode has been explored. The detection limit of the adsorptive stripping voltammetry of CLP is 8.0?10-9 mol/L under optimum condition.

Key words: clozapine, adsorptive stripping voltammetry, electrochemical characteristics

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