中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (2): 84-86.

• 研究论文 • 上一篇    下一篇

生物降解聚合物膜的制备及防肌腱粘连作用

甘志华1, 景遐斌1, 张仲文2, 徐莘香2   

  1. 1. 中国科学院长春应用化学研究所高分子物理联合开放研究实验室, 长春 130022;
    2. 白求恩医科大学第一临床医院, 长春
  • 收稿日期:1996-07-21 修回日期:1996-09-04 出版日期:1997-04-10 发布日期:1997-04-10
  • 基金资助:
    国家自然科学基金

Preparation of Biodegradable Polymer Films for Prevention of Tendon Adhesion

Gan Zhihua1, Jing Xiabin1, Zhang Zhong wen2, Xu Xingxiang2   

  1. 1. Polymer Physics Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022;
    2. Department of O rthopaedics, Norman Bethune University of Medical Sciences, Changchun
  • Received:1996-07-21 Revised:1996-09-04 Published:1997-04-10 Online:1997-04-10

PDF

577

被引次数

5 | 3

摘要： 生物降解高分子材料的最大特点是能在体液、酶和细胞等的作用下发生降解, 变成低分子物质被吸收或通过新陈代谢排出体外, 因而做为一种临时性的支架或修复材料, 如骨固定材料[ 1]、手术缝合线[ 2]、人造皮肤[ 3]等, 可以起到很好的治疗作用, 又不需二次手术取出, 可以极大地减少病人的痛苦. 粘连是外科手术中常见的后遗症. 本文将稀土配位催化剂制备的 ε-己内酯/d, l -丙交酯共聚物和 ε-己内酯均聚物, 用溶液浇铸方法成膜, 植入兔子体内, 观察了聚合物膜在兔子体内的防肌键粘连作用及生物降解行为.

关键词: 肌腱粘连, 生物降解, 聚合物膜

Abstract: ε-Caprolactone(ε-CL)/d,l lactide(DLLA)copolymer films with thickness of 40 μm were prepared by solution-casting and implanted into rabbit body to cover the ruptured achilles tendons for preventing tendon adhesion with surrounding tissues. The biodegradation of ε-CL homopolymer film and ε-CL/DLLA copolymer film in rabbit body were also studied. The ε-CL/DLLA copolymer film could decrease postoperative adhesion of the tendon, and it degraded entirely within 24 weeks.

Key words: tendon adhesion, biodegradation, polymer film

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